-
Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients A Pragmatic Trial (EVOLUTION).
This research study is being conducted to determine whether switching to an IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab ...Phase N/A
Interventional
-
The Parkinson s Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative 2.0 (PPMI 2.0) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital ...Phase N/A
Non-Interventional
-
CCI-Mobile: Signal Processing Advancements for Cochlear Implant Users in Naturalistic Environments
The proposed multi-center research effort seeks to explore the novel research directions made possible by a flexible, powerful, portable speech processor (CCi-MOBILE) for cochlear implants ...Phase N/A Non-Interventional
-
Reinforcement Learning and Attention in Decision Making
Reinforcement effects are a tenet of human decision-making under uncertainty, according to which people increase their risk-taking following a gain and decrease their risk-taking following ...Phase N/A Non-Interventional
-
Role of the Decision-Making Reference Point in Cognition and Psychopathology
Mood disorders are characterized by a tendency to subjectively evaluate objectively positive outcomes in a negative light. A fundamental feature of nearly all standard models ...Phase N/A Non-Interventional
-
Optimized sodium MR imaging at clinical field strength to study in vivo sodium signal in mild traumatic brain injury
The overall goal of this project is to detect and quantify changes in brain sodium MRI (NaMRI) signal after Mild Traumatic Brain Injury (MTBI).Phase N/A Non-Interventional
-
Rapid Motion-Robust and Easy-to-Use Dynamic Contrast-Enhanced MRI for Liver Perfusion Quantification (Non-treatment cohort)
We propose to develop new rapid MRI techniques combining novel motion-robust sampling strategies and advanced reconstruction models to address these challenges.Phase N/A Non-Interventional
-
Rapid Structure-Function MRI of the Lung for Post-COVID-19 Management
The objective of this application is to develop novel rapid free-breathing four-dimensional (4D=3D+time) lung MRI techniques that will enable non-invasive radiation-free evaluation of ...Phase N/A Non-Interventional
-
Developing a Novel Neural marker for Assessing Pathological Social Interactions
We hypothesize that pathological social interactions like those observed in Autism, arise from a failure by patients to appropriately model the thoughts and plans of ...Phase N/A Non-Interventional
-
Assessing dysarthria severity before and after neurosurgical procedures: A prospective longitudinal study in patients with refractory movement disorders
Subjects undergoing the neurosurgical high intensity focused ultrasound (HIFU) procedure as part of their standard of care for Essential Tremor (ET) will perform three sessions ...Phase N/A Non-Interventional
