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Assessment of glutamate neurotransmission brain bioenergetics and neuroinflammation in major depressive disorder using TSPO PET and MRI
The overarching goal of this study is to develop PET/MR techniques for the diagnosis of Major Depressive Disorder (MDD). Our central hypothesis is that ...Phase N/A
Non-Interventional
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Rapid Motion-Robust and Easy-to-Use Dynamic Contrast-Enhanced MRI for Liver Perfusion Quantification (Non-treatment cohort)
We propose to develop new rapid MRI techniques combining novel motion-robust sampling strategies and advanced reconstruction models to address these challenges.Phase N/A Non-Interventional
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Genetic Analysis of Hirschsprung Disease
Hirschsprung disease (HSCR) is a birth defect resulting from the absence of nerve (ganglion) cells in the gastrointestinal tract. Hirschsprung disease has a population incidence ...Phase N/A Non-Interventional
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Heart Attack Research Program (HARP)
The Heart Attack Research Program (HARP) is a multi-discipline and mutli-center study that incorporates clinical and basic science and population health to investigate mechanisms of ...Phase N/A Non-Interventional
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ADAPTATION TO FREQUENCY-PLACE FUNCTIONS IN COCHLEAR IMPLANT USERS
It is a basic study that will examine adaptation to frequency-place maps in cochlear implant users. The main outcome measures will be measures of speech ...Phase N/A Non-Interventional
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Quantitative Sodium MR Imaging and Proton MR Spectroscopy in Traumatic Brain Injury
The objectives of this study are to investigate new measures of TBI damage obtained from sodium Magnetic Resonance Imaging and to integrate sodium MRI with ...Phase N/A Non-Interventional
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Locus-coeruleus function in normal elderly and AD risk (LEAD)
Growing evidence suggests that Alzheimer’s disease (AD) pathological changes begin decades before clinical symptoms and tau abnormalities in the locus coeruleus (LC) can be ...Phase N/A
Interventional
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A prospective randomized-controlled study to evaluate the effect of a standardized yoga practice on chronic back pain
Background: Chronic low back pain is notoriously difficult to treat and is a primary contributor to lost work days and excessive health expenditures, and whose ...Phase N/A Interventional
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A Randomized Comparative Effectiveness Study of Staged Complete Revascularization with Percutaneous Coronary Intervention to Treat Coronary Artery Disease vs Medical Management Alone in Patients with Symptomatic Aortic Valve Stenosis undergoing Elective Transfemoral Transcatheter Aortic Valve Replacement: The COMPLETE TAVR Study
This study is being conducted in Aortic Stenosis patients who have undergone successful TAVR with a balloon expandable heart valve who also have coronary artery ...Phase N/A Interventional
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A prospective double-blinded randomized controlled trial evaluating effectiveness of lower tourniquet pressures in hand and upper extremity surgery
This study design is a prospective, double-blinded, randomized controlled trial evaluating the quality of bloodless surgical field with lower tourniquet pressures based on systolic blood ...Phase N/A Interventional
