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Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients A Pragmatic Trial (EVOLUTION).
This research study is being conducted to determine whether switching to an IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab ...Phase N/A
Interventional
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Site for The Parkinson s Progression Markers Initiative (PPMI) 2.0 Clinical - Establishing a Deeply Phenotyped PD Cohort
Site for The Parkinson Progression Marker Initiative 2.0 (PPMI 2.0) is a longitudinal, observational, multi-center natural history study to assess progression of clinical ...Phase N/A
Non-Interventional
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Neuroenergetic Adaptations in Alzheimer's Disease: Implications on Amyloid Burden and Cognition
Alzheimer’s disease (AD) accounts for the majority of dementia cases worldwide. The number of persons with AD in the US is expected to reach ...Phase N/A Interventional
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CCI-Mobile: Signal Processing Advancements for Cochlear Implant Users in Naturalistic Environments
The proposed multi-center research effort seeks to explore the novel research directions made possible by a flexible, powerful, portable speech processor (CCi-MOBILE) for cochlear implants ...Phase N/A Non-Interventional
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Psoriatic Response and Onset: Genes Radiology Environment Skin and Synovium)
This is a longitudinal, observational cohort study to aimed to understand the clinical and biologic underpinnings of psoriasis and psoriatic arthritis development and severity. To ...Phase N/A Non-Interventional
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Role of the Decision-Making Reference Point in Cognition and Psychopathology
Mood disorders are characterized by a tendency to subjectively evaluate objectively positive outcomes in a negative light. A fundamental feature of nearly all standard models ...Phase N/A Non-Interventional
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Optimized sodium MR imaging at clinical field strength to study in vivo sodium signal in mild traumatic brain injury
The overall goal of this project is to detect and quantify changes in brain sodium MRI (NaMRI) signal after Mild Traumatic Brain Injury (MTBI).Phase N/A Non-Interventional
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3D Free-Breathing Fat and Iron Corrected T1 Mapping
This study proposes a novel 3D liver T1 mapping technique that will enable water-specific T1 mapping (or fat/iron-corrected T1 mapping) to remove the influence ...Phase N/A Non-Interventional
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Rapid Structure-Function MRI of the Lung for Post-COVID-19 Management
The objective of this application is to develop novel rapid free-breathing four-dimensional (4D=3D+time) lung MRI techniques that will enable non-invasive radiation-free evaluation of ...Phase N/A Non-Interventional
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Assessing dysarthria severity before and after neurosurgical procedures: A prospective longitudinal study in patients with refractory movement disorders
Subjects undergoing the neurosurgical high intensity focused ultrasound (HIFU) procedure as part of their standard of care for Essential Tremor (ET) will perform three sessions ...Phase N/A Non-Interventional
