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A Phase 1/1b Study of ASP2138 in Participants With Metastatic or Locally Advanced Unresectable Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma or Metastatic Pancreatic Adenocarcinoma Whose Tumors Have Claudin (CLDN) 18.2 Expression
Claudin 18.2 protein, or CLDN18.2 is a protein found on cells in the digestive system. It is also found on some tumors. Researchers ...Phase
Interventional
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A Molecularly Driven Phase 1b Dose Escalation and Dose Expansion Study of the DNA-PK Inhibitor Peposertib (M3814) in Combination with the ATR Inhibitor M1774
This study tests the effectiveness of two drugs, peposertib (M3814) and M1774, in patients with advanced solid tumors who have certain genetic changes or signs ...
Phase
Interventional
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A Phase 1a/b Study Investigating the Safety Tolerability Pharmacokinetics Pharmacodynamics and Preliminary Antitumor Activity of BGB-58067 an MTA-Cooperative PRMT5 Inhibitor in Patients With Advanced Solid Tumors
This is an open-label, multicenter, first-in-human dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BGB-58067 ...Phase
Interventional
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A Phase 1 Open-Label Study to Evaluate the Safety Tolerability Pharmacokinetics and Efficacy of BL-M07D1 in Subjects with HER2 Expressing Advanced Malignant Solid Tumors
This is a multicenter Phase 1 study evaluating the safety, tolerability, pharmacokinetic (PK) profile, and initial efficacy of BL-M07D1 in subjects with metastatic or unresectable ...Phase
Interventional
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An Open-label Phase 1a/b Multicenter Study of ZL-6201 to Evaluate Safety Tolerability Pharmacokinetics and Preliminary Efficacy in Participants with Sarcoma and Selected Solid Tumors
This is a Phase 1 study testing a new medicine called ZL-6201 (an experimental antibody-drug conjugate - ADC) in patients with advanced bone sarcomas, soft tissue ...
Phase
Interventional
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A Phase 1 Multicenter Open-Label Dose-Escalation Study to Assess Safety Tolerability and Efficacy of EXS74539 as Monotherapy in Participants with Select Solid Tumors
This is a Phase 1 study testing a new oral drug called EXS74539 in patients with small cell lung cancer (SCLC) and other selected solid ...
Phase
Interventional
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A Phase 1 First-in-Human Study to Investigate the Safety Pharmacokinetics and Preliminary Efficacy of ML261 an Autologous Anti-DLL3 CAR + CARD11-PIK3R3 Fusion T cell therapy in Participants with Relapsed/Refractory Small Cell Lung Cancer or Select Neuroendocrine Carcinomas
This is a Phase 1, first-in-human study that is testing a new treatment called ML261 for people with certain types of cancer, specifically small cell ...
Phase
Interventional
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A Multicenter Open-Label Study of RMC-6236 in Patients with Advanced Solid Tumors Harboring Specific Mutations in RAS
A Multicenter Open-Label Study of RMC-6236 in Patients with Advanced Solid Tumors Harboring Specific Mutations in RASPhase
Interventional
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Phase 1/1b Multicenter Open-Label Study of RMC-5127 in Patients with Advanced KRAS G12V-Mutant Solid Tumors
This is a Phase 1/1b study testing RMC-5127 (investigational cancer drug) in adults with advanced solid tumors that have a KRAS G12V mutation, a ...
Phase
Interventional
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A Phase 1a/1b Trial of LY3962673 in Participants with KRAS G12D-Mutant Solid Tumors
This study is testing the tolerability, effectiveness, and potential for few side effects of the drug LY3962673 in patients with advanced solid tumors that have ...
Phase
Interventional
