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A Phase 1 Open-Label Multicenter Study to Assess the Safety Tolerability and Immunogenicity of mRNA-4157 Alone or in Combination in Participants with Solid Tumors
This is a 2-part, open-label, Phase 1, multicenter dose-escalation, FIH study of mRNA-4157 monotherapy in subjects with resected solid tumors (Part A) who are in ...Phase
Interventional
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A Phase 1b Study of Nivolumab in Patients with Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)
Nivolumab will be investigated at the Food and Drug Administration (FDA)-approved dose of 480 mg intravenous (IV) every 4 weeks until unacceptable toxicity, disease ...Phase
Interventional
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Optimal Dosing of IC-Green for Visualization of Rotator Cuff Vascularity using Advanced Imaging Modality Arthroscopy: A Prospective Randomized Trial
Rotator cuff re-tear is a common delayed complication of arthroscopic rotator cuff repair. This process of re-tear is multifactorial and there has not been any ...Phase
Interventional
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The Effect of Bone-void filler on Anterior Knee Pain Following ACL Reconstruction with Bone-Patellar Tendon Bone Autograft
This study will compare 3 commonly used bone-void fillers, autologous bone, calcium phosphate cement, and demineralized bone matrix to fill the bony defect association with ...Phase
Interventional
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Transcranial Photobiomodulation for Alzheimer's Disease
This multi-site study will be the first to evaluate the dose-dependent effects of t-PBM in amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer’s Disease ...Phase
Interventional
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Verbal Working Memory and Attention Remediation for Adults with Traumatic Brain Injury.
This project will examine if computerized cognitive remediation will improve working memory and attention in 25 adults with a brain injury and compared their cognitive ...Phase
Interventional
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A Phase 1 Open-label Preliminary Pharmacokinetics (PK)and Safety Study of CLN-049 (An fms-like tyrosine kinase 3 [FLT3] x cluster of differentiation 3 [CD3] bispecific T cell engager) in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
A Phase 1, Open-label, Preliminary Pharmacokinetics (PK)and Safety Study of CLN-049 (An fms-like tyrosine kinase 3 [FLT3] x cluster of differentiation 3 [CD3] bispecific ...Phase
Interventional
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A First in Human Study of theMenin-KMT2A (MLL1)Inhibitor JNJ-75276617 in Participants with Acute Leukemia
A First in Human Study of theMenin-KMT2A (MLL1)Inhibitor JNJ-75276617 in Participants with Acute LeukemiaPhase
Interventional
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Pilot Randomized Controlled Trial of Integrated Supportive Care with Nephrology Care
This study is a pilot randomized controlled trial testing the feasibility of an integrated supportive care approach in the ambulatory setting in nephrology as well ...Phase
Interventional
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Trametinib and Everolimus for the Treatment of Pediatric and Young Adult Patients With Recurrent Low Grade Gliomas and High Grade Gliomas (PNOC021)
Trametinib and Everolimus for the Treatment of Pediatric and Young Adult Patients With Recurrent Low Grade Gliomas and High Grade Gliomas (PNOC021)Phase
Interventional
