Displaying 710 (all) recruiting clinical trials.
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Mechanisms of Vascular Aneurysms
Our mission is to enable the use of human tissues with outcome data by basic and clinical investigators for research into the biology, causes, prevention ...Phase N/A
Non-Interventional
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Genetic evaluation of patients with undiagnosed diseases
The purpose of this study is to use extensive sequencing of the DNA (genetic material inherited from parents) or RNA (transcripts of the DNA), and ...Phase N/A Non-Interventional
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Impact of time restricted feeding in obese subjects undergoing a low-calorie diet
The impact of circadian rhythms appear to impact various biologic mechanisms including sleep, nutrition, and physical activity. We wish to understand the impact of timing ...Phase N/A
Interventional
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Multicenter Study of Epilepsy Surgery Long Term Outcomes Mortality
The Multicenter Study of Epilepsy Surgery – Long Term Outcomes Mortality study aims to examine the various aspects of epilepsy surgery outcomes after more than 10 ...Phase N/A Non-Interventional
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A Phase 2 Randomized Study of Adjuvant Immunotherapy With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab Versus Pembrolizumab Alone After Complete Resection of High-Risk Melanoma (mRNA-4157-P201)
This is an open-label, randomized, Phase 2 study. Approximately 150 eligible patients will be randomly assigned in a 2:1 ratio to the combination arm ...Phase
Interventional
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A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation
Study 849-001 is a multi-center, Phase 1/2, multiple expansion cohort trial evaluating the safety, PK, metabolites, PD and clinical activity/efficacy of MRTX849 in ...Phase
Interventional
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Cochlear implants and listening effort: the interaction of cognitive and sensory constraints
Hearing impairment is the third most prevalent chronic medical condition among older adults in the United States. Untreated, hearing loss can interfere with effective communication ...Phase N/A Non-Interventional
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THE PROSPECTIVE NATURAL HISTORY OF FAMILIAL DYSAUTONOMIA
Our ultimate goal is to develop new treatments for patients with familial dysautonomia (FD, OMIM 223900). We also want to learn which specific nerve populations ...Phase N/A Non-Interventional
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MICROBiome Involvement in Outcomes of Methotrexate Efficacy-RA
This is a prospective, observational, proof-of-principle, open-label, single-blinded study looking at the effects of the gut microbiome on the metabolism and response to methotrexate treatment ...Phase N/A Non-Interventional
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Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTIONInternational Clinical Database and Repository
Antiphospholipid syndrome (APS) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. APS can occur as a primary ...Phase N/A Non-Interventional
