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A single-center observational study of the relationship between sleep synovial fluid cytokine profiles & outcomes of ACL reconstruction
The purpose of this study is to see if there is a relationship between sleep around the time of surgery and outcomes of anterior cruciate ...Phase N/A
Non-Interventional
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Electrical stimulation of cochlear nucleus for hearing restoration
The study examines hearing and sound perception in deaf individuals who are treated with cochlear implants or auditory brainstem implants (ABIs). The goal is to ...Phase N/A Non-Interventional
Accepts Healthy Volunteer
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A Phase 1b Study of Nivolumab in Patients with Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)
We want to know the safety and tolerability of the anti-programmed death 1 (PD-1) antibody nivolumab at different dose levels for patients with autoimmune disorders ...Phase
Interventional
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A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants with Melanoma (KEYNOTE-U02): Substudy 02A
The purpose of the study is to determine the safety and tolerability of investigational treatment combinations with or without pembrolizumab or pembrolizumab alone for the ...Phase
Interventional
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A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of lnvestigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants with Melanoma (KEYNOTE-U02): Substudy 02B Ph 1/2 Substudy of 1L Oncological Treatment(s) in Advanced MEL
The purpose of the study is to assess the efficacy of investigational treatment arms (pembrolizumab monotherapy or a unique pembrolizumab-based/ non-pembrolizumab-based combination) in participants with ...Phase
Interventional
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An open label home-administered transcranial Direct Current Stimulation (tDCS) clinical trial of Unipolar Depression
The purpose of this research study is to determine the safety and efficacy of home-based noninvasive brain stimulation, transcranial direct current stimulation (tDCS), in treating ...Phase N/A Interventional
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A Phase 3 Randomized Double-blind Placebo- and Active-controlled Parallel-group Multicenter Protocol to Evaluate the Safety and Efficacy of Guselkumab Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Crohn's Disease
Under this protocol, there are 3 separate studies: a 48-week Phase 2 dose-ranging study (ie, GALAXI 1) and 2 identical 48-week Phase 3 confirmatory studies ...Phase
Interventional
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IMPROVING UNDERSTANDING OF SPEECH IN NOISE
In this study, a noise reduction algorithm will be implemented in various listening situations to evaluate its effectiveness in improving speech understanding for 100 cochlear ...Phase N/A Non-Interventional
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Sleep and Prediabetes Project
The purpose of this research study is to compare the effects of individual counseling to improve sleep, eating habits, and physical activity versus individual counseling ...Phase
Interventional
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Stroke PROTECTion with SEntinel During Transcatheter Aortic Valve Replacement
The purpose of this study is to show whether the use of Sentinel significantly reduces the risk of stroke (=72 hours) after TAVR. A TAVR ...Phase N/A Interventional
