Displaying 575 (all) recruiting clinical trials.
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Medtronic SMall Annuli Randomized To Evolut or Sapien Trial (SMART Trial)
The purpose of this study is to collect information and compare the safety and performance of self- expanding (SE) versus balloon-expandable (BE) transcatheter aortic valve ...Phase N/A
Interventional
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Phase II Trial of Radium-223 Dichloride in Combination with Paclitaxel in Patients with Bone Metastatic Breast Cancer
The purpose of the study is to determine the safety and efficacy of the combination of Radium-223 dichloride and paclitaxel. We want to know if ...Phase
Interventional
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An Open Label First in Human (FIH) Phase 1 Trial of LVGN6051 as Single Agent and in Combination with Keytruda (pembrolizumab) in Advanced or Metastatic Malignancy
The purpose of the study is to look at how your body tolerates LVGN6051, how safe LVGN6051 may be, and how LVGN6051 is taken up ...Phase
Interventional
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A multi-center randomized double-blind placebocontrolled parallel group phase III study to evaluate the efficacy and safety of LNP023 in primary IgA nephropathy patients
The purpose of the study is to find out if LNP023 (also called iptacopan) is safe and effective in people who have primary IgA Nephropathy ...Phase
Interventional
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A Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Metastatic Colorectal Cancers
The purpose of the study is to characterize the safety and efficacy profile of a combination of anti-cancer therapies in participants with previously treated metastatic ...Phase
Interventional
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A Phase 1/2 Dose Escalation And Dose Expansion Study Of BA3021 Alone And In Combination With Nivolumab In Patients With Advanced Solid Tumors
The purpose of the study is to determine and evaluate the safety, tolerability, immunogenicity, and antitumor activity of BA3021 alone and in combination with nivolumab ...Phase
Interventional
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Goal-Directed Cardiopulmonary Resuscitation in Cardiac Arrest Using a Novel Physiological Target: A Pilot Mechanistic Randomized Control Trial
The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological ...Phase
Interventional
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Post COVID-19 Hypoxemic Respiratory Failure Residual Pathophysiologic Outcomes
The purpose of this study is to learn about the natural history of COVID-19 and its causes and see what effects it has on the ...Phase N/A
Non-Interventional
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A 24-week Study to Evaluate The Safety and Efficacy of CNTX-6970 in Subjects with Moderate to Severe Knee Osteoarthritis Pain
The purpose of this study is to see if a new experimental drug, called CNTX-6970, is safe and works for people with chronic pain from ...Phase
Interventional
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Interventional randomized double-blind crossover placebo controlled exploratory phase Ib study investigating the safety tolerability pharmacokinetic and electrocorticographic response of Lu AG06466 in treatment resistant focal epilepsy patients with chronically implanted responsive neurostimulation system (RNS System).
The purpose of this study is to find out about the safety and efficacy (how well something works) of Lu AG06466 for the treatment of ...Phase
Interventional
