-
A Phase 3 Multicenter Open-Label Randomized Controlled Study of Oral Infigratinib versus Gemcitabine with Cisplatin in Subjects with Advanced/Metastatic or Inoperable Cholangiocarcinoma with FGFR2 Gene Fusions/Translocations: The PROOF Trial
The purpose of this study is to determine if the investigational drug, infigratinib, is an effective treatment for cholangiocarcinoma (bile duct cancer) compared with the ...Phase
Interventional
-
RESILIENT: REhabilitation at home uSIng mobiLe health In oldEr adults after hospitalizatioN for ischemic hearT disease
The goal of this research study is to understand whether a personalized care plan for home exercise, coupled with the use of mobile health technology ...Phase
Interventional
-
WUH: AMPLATZER Amulet Left Atrial Appendage (LAA) Occluder Randomized Controlled Trial
The purpose of the AMPLATZER Amulet Left Atrial Appendage (LAA) Occluder Trial is to find out if the Amulet device is safe and effective when ...Phase N/A Interventional
-
A PHASE 1B/2A MULTICENTER OPEN-LABEL DOSEESCALATION STUDY TO DETERMINE THE MAXIMUM TOLERATED DOSE ASSESS THE SAFETY TOLERABILITY PHARMACOKINETICS AND EFFICACY OF CC-220 MONOTHERAPY AND IN COMBINATION WITH OTHER TREATMENTS IN SUBJECTS WITH RELAPSED AND REFRACTORY MULTIPLE MYELOMA
The purpose of this study is to test the safety and to define the appropriate dose of an investigational drug (CC-220) and an investigational combination ...Phase
Interventional
-
The Role of Residual Hearing in Cochlear Implant Outcomes
The purpose of the study is to learn more about how cochlear implants benefit patients who can hear some things with hearing aids or without ...Phase N/A
Non-Interventional
Accepts Healthy Volunteer
-
A Pivotal Phase 3 Trial to Evaluate the Safety and Efficacy of Clazakizumab for Treatment of Antibody-Mediated Rejection in Kidney Transplant Recipients
The purpose of this research study is to investigate the effectiveness and safety of treatment with clazakizumab compared to a placebo (inactive substance) in kidney ...Phase
Interventional
-
Simulation Order for Patients Undergoing Robotic-based SBRT: Identifying Predictors of Lengthier Insurance Authorization
Atherosclerotic cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Obesity increases risk for coronary heart disease and stroke. Prevention or regression ...Phase N/A Non-Interventional
-
A multicenter phase 3 randomized double-blind placebo-controlled study evaluating the efficacy and safety of bimekizumab in the treatment of subjects with active psoriatic arthritis
Psoriasis is a long-term skin disease in which the skin cells grow abnormally causing a buildup of cells which appears as red, raised patches covered ...Phase
Interventional
-
VEDOKIDS study: Predicting response to Vedolizumab in Pediatric Inflammatory Bowel Diseases including drug levels: a multi-center prospective Pan- European cohort study (P-ECCO and ESPGHAN)
The purpose of this research study is to learn more about a medication used to treat crohns and ulcerative colitis. Subjects are invited to participate ...Phase N/A Non-Interventional
-
AALL1631: International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Ph+ ALL Testing Imatinib in Combination with Two Different Cytotoxic Chemotherapy Backbones
The goal of this trial is to reduce treatmentrelated morbidity and mortality without adversely impacting disease free survival (DFS) in Standard Risk (SR) patients, who ...Phase
Interventional
