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A Randomized Open-Label Multi-Centre Active Control Study Investigating the Efficacy and Safety of Imlifidase in Eliminating Donor Specific Anti-HLA Antibodies in the Treatment of Active Antibody-Mediated Rejection in Kidney Transplant Patients
The purpose of this study is to assess the effectiveness and safety of the study drug, imlifidase in patients who qualify for the study and ...Phase
Interventional
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Study of inherited monogenic disorders in patient and tissue-specific cells
The purpose of this study is to learn more about the genetic mutations (changes) associated with the genes associated with neurodevelopmental disorders like epilepsy. Genes ...Phase N/A
Non-Interventional
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An Open-Label Randomized Phase II Study of Combining Osimertinib with and without Ramucirumab in TKI-na ve EGFR-mutant Locally Advanced or Metastatic NSCLC
The purpose of this study is to find out whether the addition of ramucirumab to osimertinib is better at controlling EGFR lung cancer than just ...Phase
Interventional
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COVID 19 Intervention: Influence of ECMO on Cytokine Storm with/without Cytokine Filtration
Approximately 8-10% of ventilator dependent patients are being placed on ECMO (extracorporeal membrane oxygenation) for adult respiratory distress syndrome during the COVID 19 pandemic. The ...Phase N/A Non-Interventional
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A Randomized Placebo-Controlled Double-Blind Study of Adjuvant Cemiplimab Versus Placebo after Surgery and Radiation Therapy in Patients with High Risk Cutaneous Squamous Cell Carcinoma (CSCC); R2810-ONC-1788
The main purpose of this study is to determine if the study drug, Cemiplimab, will prevent cutaneous squamous cell cancer from returning after surgery and ...Phase
Interventional
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ACNS1833: A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
ACNS1833 is a prospective randomized phase 3 study comparing selumetinib to CV in previously untreated LGG not associated with neurofibromatosis or BRAFV600E. This non-inferiority study ...Phase
Interventional
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A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
The primary purpose of the study is to determine if a reduced dose of radiation to the whole brain and spine and less chemotherapy can ...Phase
Interventional
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Quality of Life of Patients with Single-Sided Deafness Treated with Cochlear Implantation
The purpose of this research study is to understand more about how cochlear implants affect the quality of life of patients with deafness in only ...Phase N/A Non-Interventional
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A Multicenter Clinical Trial of Intravesical Bacillus Calmetter-Guerin (BCG) in combination with ALT-803 in Patients with BCG Unresponsive High Grade non-Muscle Invasive Bladder Cancer
The purpose of the study is to assess effectiveness and safety of the intravesical BCG (Bacillus Calmetter-Guerin) in combination with ALT-803 in patients with BCG ...Phase
Interventional
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Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites
This purpose of the study is to determine the effectiveness of the treatments including motivational interviewing, nicotine replacement therapy patch, NRT Lozenge, and message framing ...Phase N/A Interventional
