Displaying 741 (all) recruiting clinical trials.
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TSPO-ligand PET imaging in autoimmune epilepsy
The purpose of this study is to use PET/MRI imaging to measure levels of inflammation in the brain of people with autoimmune epilepsy compared ...Phase N/A
Non-Interventional
Accepts Healthy Volunteer
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WUH: Characterization of microsomal triglyceride transfer protein (MTP) in metabolic and gastrointestinal tissue in obese and other subjects undergoing therapeutic surgeries.
Microsomal triglyceride transfer protein (MTP) is an enzyme that is responsible for fat and cholesterol metabolism. Blocking the effect of MTP may be helpful in ...Phase N/A Non-Interventional
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A Phase 3 Study of I-Metaiodobenzylguanidine or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)
?The primary purpose of the study is to assess the effectiveness and safety of targeted radiopharmaceutical therapy with 131I-MIBG or crizotinib for patients with high-risk ...Phase
Interventional
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A Phase 3 Study of I-Metaiodobenzylguanidine (I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)
?The primary purpose of the study is to determine the effectiveness and tolerability of the experimental drug I-MIBG or the experimental drug crizotinib for high ...Phase
Interventional
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Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
The primary purpose of the study is to determine if accelerated BEP ((Bleomycin, Etoposide, and cisPlatin) is effective and tolerable for patients with advanced germ ...Phase
Interventional
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Study of inherited monogenic disorders in patient and tissue-specific cells
The purpose of this study is to learn more about the genetic mutations (changes) associated with the genes associated with neurodevelopmental disorders like epilepsy. Genes ...Phase N/A Non-Interventional
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An Open-Label Randomized Phase II Study of Combining Osimertinib with and without Ramucirumab in TKI-na ve EGFR-mutant Locally Advanced or Metastatic NSCLC
The purpose of this study is to find out whether the addition of ramucirumab to osimertinib is better at controlling EGFR lung cancer than just ...Phase
Interventional
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COVID 19 Intervention: Influence of ECMO on Cytokine Storm with/without Cytokine Filtration
Approximately 8-10% of ventilator dependent patients are being placed on ECMO (extracorporeal membrane oxygenation) for adult respiratory distress syndrome during the COVID 19 pandemic. The ...Phase N/A Non-Interventional
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A Randomized Placebo-Controlled Double-Blind Study of Adjuvant Cemiplimab Versus Placebo after Surgery and Radiation Therapy in Patients with High Risk Cutaneous Squamous Cell Carcinoma (CSCC); R2810-ONC-1788
The main purpose of this study is to determine if the study drug, Cemiplimab, will prevent cutaneous squamous cell cancer from returning after surgery and ...Phase
Interventional
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ACNS1833: A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
ACNS1833 is a prospective randomized phase 3 study comparing selumetinib to CV in previously untreated LGG not associated with neurofibromatosis or BRAFV600E. This non-inferiority study ...Phase
Interventional
