Displaying 651 (all) recruiting clinical trials.
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DAY101-001/PNOC026/FIREFLY-1: A Phase 2 Open-Label Multicenter Study to Evaluate the Safety and Efficacy of the Oral Pan-RAF Inhibitor DAY101 in Pediatric Patients with BRAF-Altered Recurrent or Progressive Low-Grade Glioma
The purpose of the study is to evaluate the safety and efficacy of oral pan-RAF inhibitor DAY101 in pediatric, adolescent, and young adult patients with ... -
The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): COMPASSHER2 Residual Disease (RD) A Double-Blinded Phase III Randomized Trial of T-DM1 Compared with T-DM1 and Tucatinib
The purpose of the study is to determine if the invasive disease-free survival (iDFS) with T-DM1 and tucatinib is superior to the iDFS in the ... -
A One Year Observational Investigation of Subjects with Open Angle Glaucoma And a Documented History of Progressive Visual Field Loss
The purpose of this study is to examine which ophthalmic measures routinely used in eye doctor’s offices can find changes in glaucoma the earliest ... -
Photobiomodulation Therapy Using the MuReva Phototherapy System to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Patients with Head and Neck Cancer Receiving Concurrent Radiation and Chemotherapy
The overall purpose of this clinical study is to evaluate safety and efficacy of the MuReva Phototherapy System with a light delivery mouthpiece to reduce ... -
A multipart exploratory study to evaluate splenic nerve stimulation in patients with rheumatoid arthritis.
The purpose of this research study is to test an investigational device and its accessories to help determine whether this study device may be used ... -
A Phase 1 Open-label Preliminary Pharmacokinetics (PK) and Safety Study of CLN-049 (An fms-like tyrosine kinase 3 [FLT3] x cluster of differentiation 3 [CD3] bispecific T cell engager) in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)
The purpose of the study is to determine the safety and tolerability of intravenous (IV) administered CLN-049. CLN-049 is a novel BITE therapy that target ... -
A Single-Center Observational Study of Targeted Muscle Reinnervation in Amputees
The purpose of this study is to follow the course of treatment and recovery of patients amputation, with and without targeted muscle reinnervation (TMR). Participating ... -
A pilot proof of concept study of the Effects of Administration of SCFA in Rheumatoid Arthritis (EASi-RA)
The purpose of this research is to study the effects of administering an oral short chain fatty acid (SCFA) dietary supplement along with methotrexate as ... -
Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations
The purpose of this study is to determine if a protein called fibroblast growth factor-2 (FGF-2) can be safely put on the eardrum and help ... -
Patient Expectations Following Flexor Tendon Repair
The purpose of this research study is to examine what patients expect to experience following surgical repair of a flexor tendon injury. Recovery from a ...