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Paradoxical Lucidity in Severe End-Stage Dementia: A Mixed Methods Prospective Study
Many people with severe dementia lose their memory, their ability to communicate with others or care for themselves. Sometimes, though, these people may experience an ... -
A Randomized Comparative Effectiveness Study of Staged Complete Revascularization with Percutaneous Coronary Intervention to Treat Coronary Artery Disease vs Medical Management Alone in Patients with Symptomatic Aortic Valve Stenosis undergoing Elective
The purpose of this study is to find out, in patients with coronary artery disease (CAD) who had successful transcatheter aortic valve replacement (TAVR) with ... -
Depression treatment and A dynamics: A study of Alzheimer s disease risk
The purpose of this research study is to test if a reduction in depressive symptoms in response to treatment with an antidepressant improves levels of ... -
Lung and Diaphragm Ultrasound in Dyspneic Patients
Shortness of breath is one of the most common symptoms experienced by patients with lung conditions. Patients with shortness of breath frequently undergo many tests ... -
A Phase 2 Open-label Multicenter Cohort Study of ALKS 4230 Monotherapy Administered Subcutaneously in Patients With Advanced Cutaneous Melanoma or Intravenously in Patients With Advanced Mucosal Melanoma Who Have Previously Received Anti-PD-[L]1 Therapy - ARTISTRY-6
The purpose of the study is to evaluate the antitumor activity, safety and tolerability of ALKS 4230 given as monotherapy in patients with unresectable and ... -
MASALA Study Expansion
The purpose of this research study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those ... -
The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis (SAVVE) Study
The purpose of this study is to learn whether the Hancock Jaffe bioprosthetic venous valve(VenoValve®) will help subjects like you with severe chronic venous ... -
A Multi-Center study in Patients Undergoing Total Knee Replacement with Smith+Nephew Porous Total Knee Arthroplasty (TKA) Systems
The purpose of this study is to assess the safety and effectiveness of the Porous Total Knee System. The total knee system is made up ... -
A Phase I First-In-Human Multicenter Open-Label Study of Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors
The purpose of the study is to determine the safety, tolerability, and immunogenicity, and to detect any preliminary evidence of anti-tumor activity of Nous-209 genetic ... -
A randomized phase II trial of adjuvant trastuzumab emtansine (T-DM1) followed by subcutaneous trastuzumab versus paclitaxel in combination with subcutaneous trastuzumab for Stage I HER2-positive breast cancer (ATEMPT 2.0)
In stage 1 (early) HER2+ breast cancer, lesser chemotherapy is needed to achieve excellent long-term survival. The current standard therapy is TH (paclitaxel plus trastuzumab ...