Displaying 633 (all) recruiting clinical trials.
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Mechanisms of Vascular Aneurysms
Our mission is to enable the use of human tissues with outcome data by basic and clinical investigators for research into the biology, causes, prevention ...Phase N/A
Non-Interventional
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Genetic evaluation of patients with undiagnosed diseases
The purpose of this study is to use extensive sequencing of the DNA (genetic material inherited from parents) or RNA (transcripts of the DNA), and ...Phase N/A Non-Interventional
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Impact of time restricted feeding in obese subjects undergoing a low-calorie diet
The impact of circadian rhythms appear to impact various biologic mechanisms including sleep, nutrition, and physical activity. We wish to understand the impact of timing ...Phase N/A
Interventional
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Does the Presence of Preoperative Proteinuria Predict Postoperative Acute Kidney Injury in Obese Patients Undergoing Elective Laparoscopic Surgery?
The research design of this study is a prospective cohort study. Potential subjects will be any patients undergoing elective laparoscopic weight loss surgery including: gastric ...Phase N/A Non-Interventional
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Quantitative Sodium MR Imaging and Proton MR Spectroscopy in Traumatic Brain Injury
The objectives of this study are to investigate new measures of TBI damage obtained from sodium Magnetic Resonance Imaging and to integrate sodium MRI with ...Phase N/A Non-Interventional
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A Phase 2 Randomized Study of Adjuvant Immunotherapy With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab Versus Pembrolizumab Alone After Complete Resection of High-Risk Melanoma (mRNA-4157-P201)
This is an open-label, randomized, Phase 2 study. Approximately 150 eligible patients will be randomly assigned in a 2:1 ratio to the combination arm ...Phase
Interventional
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SWIFT TRIAL: SURGICAL WEIGHT-LOSS TO IMPROVE FUNCTIONAL STATUS TRAJECTORIES FOLLOWING TOTAL KNEE ARTHROPLASTY
We will compare long-term outcomes in the test and control arms of the study. These outcomes will include measures of physical function, mobility, indices of ...Phase N/A Interventional
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Zenith p-Branch Pivotal Study
This clinical investigation is intended to evaluate the safety and effectiveness of the Zenith® p-Branch™ in combination with Atrium iCAST™ covered stents for the treatment ...Phase
Interventional
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A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation
Study 849-001 is a multi-center, Phase 1/2, multiple expansion cohort trial evaluating the safety, PK, metabolites, PD and clinical activity/efficacy of MRTX849 in ...Phase
Interventional
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Cochlear implants and listening effort: the interaction of cognitive and sensory constraints
Hearing impairment is the third most prevalent chronic medical condition among older adults in the United States. Untreated, hearing loss can interfere with effective communication ...Phase N/A Non-Interventional
