Displaying 648 (all) recruiting clinical trials.
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The effect of transcutaneous auricular vagal nerve stimulation on pupillary response and perceptual learning.
Study 1: We will observe the use of taVNS versus sham setting(s) on healthy human subjects and observe pupillary response in a passive study ...Phase N/A
Interventional
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PRESERVE Heart Study
Heart transplantation has long proven success for the treatment of end stage organ disease, and preservation of the heart prior to transplant remains an important ...Phase
Interventional
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A PHASE 3 MULTI-CENTER RANDOMIZED DOUBLE-BLIND TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF AFICAMTEN COMPARED TO PLACEBO IN ADULTS WITH SYMPTOMATIC NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY
This is a Phase 3, multi-center, randomized, double-blind, placebo-controlled trial in participants with symptomatic nHCM. Approximately 420 eligible participants will be randomized in a 1 ...Phase
Interventional
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Development and Piloting of a Family-Centered mHealth-Enhanced Intervention to Promote Caregiving Mastery in Detection Prevention and Management of Delirium Superimposed on Dementia
Delirium superimposed on dementia (DSD) is an acute and serious condition that is common in persons living with dementia (PLWD). Involvement of family caregivers can ...Phase
Interventional
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An Open Label Multi-Center Retrospective and Prospective Evaluation of Equinoxe Proximal Humerus Fracture Plates Clinical and Radiographic Outcomes
The primary objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data to better understand the safety and performance of ...Phase N/A
Non-Interventional
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5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
This study will be a multi-site, double-blind, randomized clinical trial of the 5-HT2A receptor agonist psilocybin for smoking cessation. The current trial will be conducted ...Phase
Interventional
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The effects of Gender-Affirming Hormone Therapy (GAHT) on blood pressure of transgender adolescents as measured by ambulatory blood pressure monitoring (ABPM) over the first year of therapy
The goal of this study is to inform regarding effects of GAHT on blood pressure, to help improve clinical practice guidelines regarding screening and treatment ...Phase N/A Non-Interventional
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A SINGLE CENTER PILOT STUDY ESTABLISHING TEST-RETEST RELIABILITY OF SWALLOWING PRESSURES COLLECTED WITH HIGH RESOLUTION PHARYNGEAL MANOMETRY (HRPM)
Difficulty swallowing (known as dysphagia) can have devastating consequences for health and quality of life. The current gold-standard assessment tool, videofluoroscopy (VF), allows real time ...Phase N/A Non-Interventional
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A Stepped-Care Approach to Treating Dental Fear: A Sequential Multiple Assignment Randomized Trial for Cognitive-Behavioral Treatment via Mobile App and Evidence-Based Collaborative Care
A Sequential Multiple Assignment Randomized Treatment (SMART) design will be used to assess the effectiveness of a virtual stepped-care (progressive dosing) approach to dental fear ...Phase
Interventional
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A Phase 2 Randomized Double-Blind Placebo-Controlled Study to Assess the Efficacy and Safety of Barzolvolimab (CDX-0159) in Adults with Active Eosinophilic Esophagitis (The EvolvE Study)
To evaluate efficacy of barzolvolimab, compared to placebo, in reducing esophageal intraepithelial infiltration of mast cells as assessed by peak esophageal intraepithelial mast cell (PMC ...Phase
Interventional
