Displaying 502 (all) recruiting clinical trials.
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A Phase 1 Study of the Polymerase Theta Inhibitor Novobiocin in BRCA-Mutant and Other DNA Damage Repair-Deficient Solid Tumors
To determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of novobiocin administered on a 5-days on/2-days off schedule in patients ...Phase
Interventional
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A Phase 1 Study of Lenalidomide in Combination with EPOCH Chemotherapy for HTLV-Associated Adult T-Cell Leukemia-Lymphoma (ATLL)
This study is being done to determine if we can combine lenalidomide with full doses of EPOCH chemotherapy for your ATLL, and to define the ...Phase
Interventional
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A Multi-Center Prospective Registry to Evaluate the Continued Safety and Effectiveness of Arthrex Products used for Knee Sports Medicine Repair and Reconstruction
The study is being done to evaluate the effectiveness and safety profile of Arthrex knee products when used as standard of care for repair or ...Phase N/A Interventional
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Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) For Intact Brain Metastases
This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has ...Phase
Interventional
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Evaluation of the MISHA Knee System for Symptom Relief in Subjects with Medial Knee Osteoarthritis versus the use of non-surgical treatment: Randomized Assessment and Comparison of Therapies for Medial Knee Osteoarthritis
The purpose of this research study is to evaluate how well the MISHA Knee System helps reduce symptoms of medial knee osteoarthritis compared to non-surgical ...Phase N/A Interventional
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Pivotal Study to Evaluate the Safety and Effectiveness of the CereVasc eShunt System in the Treatment of Normal Pressure Hydrocephalus (STRIDE)
This research study is being done to see if the eShunt System is safe and effective in improving normal pressure hydrocephalus (NPH) symptoms.Phase N/A Interventional
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A Phase 1 Open-Label Multicenter Study to Assess the Safety Tolerability Pharmacokinetics and Anti-tumor Efficacy of DZD6008 in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) with EGFR Mutation (TIAN-SHAN1)
This is a phase 1 study testing a new medicine called DZD6008 (an EGFR inhibitor) in patients with lung cancer with EGFR mutation.
This study ...
Phase
Interventional
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WATCHMAN FLX Pro Left Atrial Appendage Closure Device with Alternative Post-Implant Monotherapy
The WATCHMAN Implant is an alternative for Atrial fibrillation (AF) patients who cannot tolerate long-term blood thinner medication.
Typically, after the WATCHMAN procedure, a doctor ...Phase N/A Interventional
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Prospective Multicenter Single-Arm Investigational Device Exemption (IDE) Study of the Shockwave Intravascular Lithotripsy (IVL) System with the Shockwave Javelin Coronary IVL Catheter (FORWARD CAD IDE Study)
The purpose of this research study is to assess the safety and effectiveness of a new, investigational catheter for use with the Shockwave Intravascular Lithotripsy ...Phase N/A Interventional
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A Phase 3 Randomized Multicenter Double-Blind Placebo-Controlled Study of Acoramidis for Transthyretin Amyloidosis Prevention in the Young (ACT-EARLY Trial)
The purpose of this research study is to see if an investigational drug, acoramidis (AG10), is safe and effective in preventing or delaying symptoms of ...Phase
Interventional
