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A Phase 2 Study of BIO 300 in Patients with COVID-19
COVID-19 is caused by a virus that triggers inflammation of the lungs. This inflammation may damage the lungs and lead to scarring. This scarring causes ...Phase
Interventional
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Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2)
The purpose of the study is to evaluate the biological activity of systemic therapies in people with Neurofibromatosis type 2 (NF2) related tumors. Tumor types ...Phase
Interventional
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Phase II pilot study of FOLFOXIRI plus panitumumab in metastatic RAS wild-type left-sided colorectal cancer
The purpose of this study is to evaluate the effectiveness (percent of patients with measurable response) of FOLFOXIRI and panitumumab for treatment of metastatic left ...Phase
Interventional
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A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED PARALLEL GROUP MULTICENTER TRIAL OF CVL-865 AS ADJUNCTIVE THERAPY IN ADULTS WITH DRUG-RESISTANT FOCAL ONSET SEIZURES (REALIZE TRIAL)
The purpose of this study is to learn how well an investigational drug (referred to as “study drug”) called CVL-865 works as a possible treatment ...Phase
Interventional
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Evaluation of Efficacy Safety and Tolerability of NGM282 (Aldafermin) in a Phase 2b Randomized Double-blind Placebo-controlled Multi-center Study in Subjects with Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (ALPINE 4)
The purpose of the study is to examine the effectiveness of aldafermin for the treatment of cirrhosis caused by nonalcoholic steatohepatitis (NASH). The study will ...Phase
Interventional
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A PHASE IB-II STUDY OF HIGH-DOSE POST-TRANSPLANT CYCLOPHOSPHAMIDE BORTEZOMIB ABATACEPT AND SHORT-DURATION TACROLIMUS FOR THE PREVENTION OF GRAFT-VERSUS-HOST DISEASE (GVHD) FOLLOWING HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT)
The purpose of the study is to determine the safety and efficacy of cyclophosphamide, abatacept, and short-duration tacrolimus for GvHD prophylaxis following haploidentical hematopoietic stem ...Phase
Interventional
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A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
This is a research study to evaluate the safety and effectiveness of the study drug donanemab to see if it will help slow the mental ...Phase
Interventional
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A Randomized Double-Blind Placebo-Controlled. Multi-center Proof-of-Mechanism Phase 2a Study to Evaluate the Safety Tolerability and efficacy of TAK-018 (EB8018) for the Prevention of Post-Operative Crohn s Disease Recurrence.
The main purpose of this study is to evaluate how safe and tolerable a drug called TAK-018 (or sibofimloc,the “Takeda Study Drug”) is in ...Phase
Interventional
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A PHASE II SINGLE-ARM STUDY OF TOTAL BODY IRRADIATION WITH LINAC BASED VOLUMETRIC MODULATED ARC THERAPY (VMAT) AND IMAGE GUIDED RADIATION THERAPY (IGRT)
The purpose of the study is to determine the safety and efficacy of delivering total body irradiation (TBI) with linac based VMAT technique for patients ...Phase
Interventional
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A Phase 2 Umbrella Study with Rolling Arms of Investigational Agents with either Pembrolizumab in Combination with Chemotherapy or with Pembrolizumab Alone in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
The purpose of the study is to determine how well different drugs work in a single type of cancer for patients with advanced NSCLC. This ...Phase
Interventional
