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Multicenter Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy Safety and Tolerability of 36 weeks of treatment with NLY01 in Early-Stage Parkinson s Disease
Parkinson’s disease is a condition that interferes with body movement. The condition usually worsens over time. Research suggests that inflammation in certain areas of ...Phase
Interventional
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Safety and Efficacy of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)
This study is being done to learn more about AMG 570 in people with systemic lupus erythematosus (SLE). The purpose of the study is to ...Phase
Interventional
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Flexible Surface Coil for MRI
The purpose of this study is to test if we can use a redesigned device of the Magnetic Resonance Imaging (MRI) scanner, called a coil ...Phase
Interventional
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A PHASE II OPEN-LABEL MULTICENTER STUDY EVALUATING THE SAFETY AND EFFICACY OF NEOADJUVANT AND ADJUVANT TIRAGOLUMAB PLUS ATEZOLIZUMAB WITH OR WITHOUT PLATINUM-BASED CHEMOTHERAPY IN PATIENTS WITH PREVIOUSLY UNTREATED LOCALLY ADVANCED RESECTABLE STAGE II IIIA OR SELECT IIIB NON-SMALL CELL LUNG CANCER
The purpose of the study is to determine the surgical safety and feasibility of atezolizumab plus tiragolumab alone (Atezo and Tira) or in combination with ...Phase
Interventional
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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1 BRCA2 or PALB2 Mutation
This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that ...Phase
Interventional
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GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients
The purpose of the trial is to assess the safety and efficacy of the Gene Mediated Cytotoxic Immunotherapy (GMCI) added to standard of care immune ...Phase
Interventional
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A Multicenter Randomized Double-Blind Placebo-Controlled Study to Evaluate Efficacy and Safety of VQW-765 in Patients with Performance Anxiety
Performance anxiety is a type of anxiety disorder characterized by excessive fear, discomfort, and self-consciousness in a variety of social situations related to performing in ...Phase
Interventional
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DAY101-001/PNOC026/FIREFLY-1: A Phase 2 Open-Label Multicenter Study to Evaluate the Safety and Efficacy of the Oral Pan-RAF Inhibitor DAY101 in Pediatric Patients with BRAF-Altered Recurrent or Progressive Low-Grade Glioma
The purpose of the study is to evaluate the safety and efficacy of oral pan-RAF inhibitor DAY101 in pediatric, adolescent, and young adult patients with ...Phase
Interventional
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AALL1821: A Phase 2 Study of Blinatumomab (NSC# 765986 IND# 125462) in Combination with Nivolumab (NSC# 748726 IND# 125462) a Checkpoint Inhibitor of PD-1 in B-ALL Patients Aged >/=1 to
The purpose of the study is to investigates how well nivolumab when given together with blinatumomab work compared to blinatumomab alone in treating patients with ...Phase
Interventional
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Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations
The purpose of this study is to determine if a protein called fibroblast growth factor-2 (FGF-2) can be safely put on the eardrum and help ...Phase
Interventional
