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MICROBiome Involvement in Outcomes of Methotrexate Efficacy-RA
This is a prospective, observational, proof-of-principle, open-label, single-blinded study looking at the effects of the gut microbiome on the metabolism and response to methotrexate treatment ...Phase N/A
Non-Interventional
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Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTIONInternational Clinical Database and Repository
Antiphospholipid syndrome (APS) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. APS can occur as a primary ...Phase N/A Non-Interventional
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OUTCOMES AFTER REPAIR OF CHRONIC PECTORALIS MAJOR RUPTURE WITH ACHILLES TENDON ALLOGRAFT
We are studying outcomes and comparing strength between the affected and unaffected arm in patients who have undergone surgical repair or reconstruction of a chronic ...Phase N/A Non-Interventional
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Gaucher Disease Outcome Survey (GOS)
The Gaucher Outcome Survey (GOS) is a long term observational survey. This survey aims to collect as much information as possible from as many Gaucher ...Phase N/A Non-Interventional
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Anomalous Aortic Origin of a Coronary Artery (AAOCA): Establishing a Multi-Institutional Registry
This is a retrospective and longitudinal cohort study. Subjects will be enrolled either when identified from medical records or when diagnosed with AAOCA. Baseline demographics ...Phase N/A Non-Interventional
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Site for WUH APOLLO TRIAL: Transcatheter Mitral Valve Replacement with the Medtronic Intrepid TMVR System in patients with severe symptomatic mitral regurgitation APOLLO Trial
Site for Multi-center, global, prospective, randomized, interventional, pre-market trial Subjects will be randomized on 1:1 basis to either TMVR with the Medtronic Intrepid™ TMVR ...Phase N/A
Interventional
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Combined Craniomaxillofacial and Upper Extremity Allotransplantation
The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have ...Phase N/A Interventional
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Transcatheter Mitral Valve Replacement with the Medtronic Intrepid TMVR System in patients with severe symptomatic mitral regurgitation APOLLO Trial
The purpose of the study is to evaluate the safety and efficacy of Medtronic Intrepid™ TMVR System in patients with severe symptomatic mitral regurgitation. Subjects ...Phase N/A Interventional
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The Role of Residual Hearing in Cochlear Implant Outcomes
Cochlear implants (CIs) have the potential to restore high frequency hearing electrically while maintaining residual low frequency hearing, allowing for simultaneous electric and acoustic listening ...Phase N/A Non-Interventional
Accepts Healthy Volunteer
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Microbial and human biomarkers of thoracic disease after lung transplantation
We will prospectively collect airway and blood samples on 200 subjects undergoing lung transplantation. We will evaluate airway microbial signatures associated with local (lower airway ...Phase N/A Non-Interventional
