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THE PROSPECTIVE NATURAL HISTORY OF FAMILIAL DYSAUTONOMIA
Our ultimate goal is to develop new treatments for patients with familial dysautonomia (FD, OMIM 223900). We also want to learn which specific nerve populations ...Phase N/A
Non-Interventional
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MICROBiome Involvement in Outcomes of Methotrexate Efficacy-RA
This is a prospective, observational, proof-of-principle, open-label, single-blinded study looking at the effects of the gut microbiome on the metabolism and response to methotrexate treatment ...Phase N/A Non-Interventional
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Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTIONInternational Clinical Database and Repository
Antiphospholipid syndrome (APS) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. APS can occur as a primary ...Phase N/A Non-Interventional
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Utility of Remote Home Monitoring Post Valvular Procedures
The objective of this study is to assess the impact of remote monitoring using Medtronic Care Management Services (MCMS) on length of stay.Phase N/A Non-Interventional
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The natural history of partial ligamentous tears in the wrist: a single-center observational study
Partial tears of the scapholunate ligament (SLL) and triangular fibrocartilage complex (TFCC) are common, but their natural history is poorly understood. The majority of these ...Phase N/A Non-Interventional
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OUTCOMES AFTER REPAIR OF CHRONIC PECTORALIS MAJOR RUPTURE WITH ACHILLES TENDON ALLOGRAFT
We are studying outcomes and comparing strength between the affected and unaffected arm in patients who have undergone surgical repair or reconstruction of a chronic ...Phase N/A Non-Interventional
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Gaucher Disease Outcome Survey (GOS)
The Gaucher Outcome Survey (GOS) is a long term observational survey. This survey aims to collect as much information as possible from as many Gaucher ...Phase N/A Non-Interventional
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Anomalous Aortic Origin of a Coronary Artery (AAOCA): Establishing a Multi-Institutional Registry
This is a retrospective and longitudinal cohort study. Subjects will be enrolled either when identified from medical records or when diagnosed with AAOCA. Baseline demographics ...Phase N/A Non-Interventional
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Multicenter Randomized Pragmatic Clinical Trial Comparing Two- Versus Three-Antibiotic Therapy for Pulmonary Mycobacterium avium Complex Disease
To determine whether 2-drug is non-inferior to 3-drug (standard) therapy against pulmonary Mycobacterium avium complex (MAC) and whether 2-drug therapy is better tolerated than 3-drug ...Phase N/A
Interventional
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Site for WUH APOLLO TRIAL: Transcatheter Mitral Valve Replacement with the Medtronic Intrepid TMVR System in patients with severe symptomatic mitral regurgitation APOLLO Trial
Site for Multi-center, global, prospective, randomized, interventional, pre-market trial Subjects will be randomized on 1:1 basis to either TMVR with the Medtronic Intrepid™ TMVR ...Phase N/A Interventional
