Displaying 661 (all) recruiting clinical trials.
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A Phase 2 Randomized Study of Adjuvant Immunotherapy With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab Versus Pembrolizumab Alone After Complete Resection of High-Risk Melanoma (mRNA-4157-P201)
This is an open-label, randomized, Phase 2 study. Approximately 150 eligible patients will be randomly assigned in a 2:1 ratio to the combination arm ...Phase
Interventional
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A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation
Study 849-001 is a multi-center, Phase 1/2, multiple expansion cohort trial evaluating the safety, PK, metabolites, PD and clinical activity/efficacy of MRTX849 in ...Phase
Interventional
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Cochlear implants and listening effort: the interaction of cognitive and sensory constraints
Hearing impairment is the third most prevalent chronic medical condition among older adults in the United States. Untreated, hearing loss can interfere with effective communication ...Phase N/A
Non-Interventional
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THE PROSPECTIVE NATURAL HISTORY OF FAMILIAL DYSAUTONOMIA
Our ultimate goal is to develop new treatments for patients with familial dysautonomia (FD, OMIM 223900). We also want to learn which specific nerve populations ...Phase N/A Non-Interventional
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MICROBiome Involvement in Outcomes of Methotrexate Efficacy-RA
This is a prospective, observational, proof-of-principle, open-label, single-blinded study looking at the effects of the gut microbiome on the metabolism and response to methotrexate treatment ...Phase N/A Non-Interventional
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Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTIONInternational Clinical Database and Repository
Antiphospholipid syndrome (APS) is a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. APS can occur as a primary ...Phase N/A Non-Interventional
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Utility of Remote Home Monitoring Post Valvular Procedures
The objective of this study is to assess the impact of remote monitoring using Medtronic Care Management Services (MCMS) on length of stay.Phase N/A Non-Interventional
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The natural history of partial ligamentous tears in the wrist: a single-center observational study
Partial tears of the scapholunate ligament (SLL) and triangular fibrocartilage complex (TFCC) are common, but their natural history is poorly understood. The majority of these ...Phase N/A Non-Interventional
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OUTCOMES AFTER REPAIR OF CHRONIC PECTORALIS MAJOR RUPTURE WITH ACHILLES TENDON ALLOGRAFT
We are studying outcomes and comparing strength between the affected and unaffected arm in patients who have undergone surgical repair or reconstruction of a chronic ...Phase N/A Non-Interventional
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Gaucher Disease Outcome Survey (GOS)
The Gaucher Outcome Survey (GOS) is a long term observational survey. This survey aims to collect as much information as possible from as many Gaucher ...Phase N/A Non-Interventional
