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A PHASE 1B OPEN-LABEL MULTICENTER STUDY TO INVESTIGATE THE SAFETY AND PRELIMINARY EFFICACY OF NKTR 214 IN COMBINATION WITH ANTI-PD-1 (PEMBROLIZUMAB) FOR PATIENTS WITH LOCALLY ADVANCED OR METASTATIC MELANOMA LOCALLY ADVANCED OR METASTATIC UROTHELIAL BLADDER CANCER OR METASTATIC NON-S ALL CELL LUNG CANCER
If you have been diagnosed with locally advanced or metastatic (the spread of) melanoma, locally advanced or metastatic (the spread of) urothelial bladder cancer or ...Phase
Interventional
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Genetic Analysis of Hirschsprung Disease
This research is being done to identify genes that are involved in the development of, or susceptibility to, the birth defect termed Hirschsprung disease (HSCR ... -
TARGET-IBD: A 5-year longitudinal observational study of patients undergoing therapy for inflammatory bowel disease (IBD)
This study is looking to enroll patients with inflammatory bowel disease (IBD), which may include Crohn's disease (CD), ulcerative colitis (UC) and Indeterminate Colitis ... -
The effect of Transjugular Intraheptic Portosystemic Shunt (TIPS) on gastrointestinal motility and the gut microbiota.
The effect of portal hypertension on gastrointestinal motility, and how reversal or improvement in portal hypertension may alter gastrointestinal motility, remains unclear and further research ...Phase N/A
Observational
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A Phase 1a/1b Dose Escalation and Expansion Trial of TTI-621 a Novel Biologic Targeting CD47 in Subjects with Relapsed or Refractory Hematologic Malignancies and Selected Solid Tumors
If you have been diagnosed with Lymphoma, Leukemia, Myelodysplastic syndrome, Myeloproliferative neoplasms, or Multiple myeloma, that has returned or worsened since your previous treatment, you ...Phase
Interventional
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CDA Diefenbach Medpace Protocol ID ME-522-001 titled: A Phase 1 Open-label Study of Voruciclib in Subjects with Relapsed and/or Refractory B Cell Malignancies After Failure of Prior Standard Therapies
If you have been diagnosed with a B cell type cancer that has relapsed (come back) or is refractory (did not respond to previous treatment ...Phase
Interventional
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Functional Brain Imaging in Healthy Volunteers and Epilepsy Patients to Study Cognitive Functions
The purpose of this protocol is to learn about scale-free brain activity as well as conscious vs. unconscious processing in the brain. To improve such ...Phase N/A
Accepts Healthy Volunteer
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Promoting Safe Use of Children's Cough/Cold Medicines
The objective of the study is to provide the necessary evidence to identify best practices for the labeling and dosing of over-the-counter pediatric cough and ...Phase N/A Accepts Healthy Volunteer
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Combined Phase 3 Double-blind Randomized Placebo-Controlled Studies Evaluating the Efficacy and Safety of Filgotinib in the Induction and Maintenance of Remission in Subjects with Moderately to Severely Active Crohn's Disease
The primary objectives of this study are to evaluate the safety and efficacy of filgotinib during induction and maintenance treatment of moderately to severely active ...Phase
Interventional
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Reduction of Pro-Inflammatory Synovial Fluid Biomarkers in Osteoarthritic of the knee wuth Alpha-2-Macroglobulin: A Randomized Controlled Trial
The purpose of the current study is to assess the ability of alpha-2-macroglobulin treatment to reduce pain and inflammation in patients with arthritis of the ...Phase
Interventional
