-
A Phase 2 randomized open-label three-arm clinical study to evaluate the safety and efficacy of lenvatinib (E7080/MK-7902) in combination with pembrolizumab (MK-3475) versus standard of care chemotherapy and lenvatinib monotherapy in participants with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) that have progressed after platinum therapy and immunotherapy (PD-1/PD-L1 inhibitors) (LEAP-009)
The purpose of the study is to evaluate the safety and efficacy of Lenvatinib with or without pembrolizumab versus standard of care chemotherapy, for previously ...Phase
Interventional
-
Promoting adherence in upper extremity home-based rehabilitation through motivational interviewing and ecological momentary assessment: A mixed methods feasibility study
The purpose of this research study is to determine the pros and cons of delivering a new arm training program completed in the participants’ homes ...Phase N/A Interventional
-
A pilot neuroimaging study of adults with prolonged grief disorder (PGD) compared to bereaved controls after death of a spouse or parent
The purpose of this study is to examine how emotional responses to the death of a spouse or partner are reflected in brain regions measured ...Phase N/A
Non-Interventional
Accepts Healthy Volunteer
-
Study to Optimize Immune Coverage of SARS-CoV-2 Existing and Emerging Variants COVAIL Booster Study
The purpose of this research is to test additional vaccine booster shots that use different vaccine types and/or variant spikes to see if these ...Phase
Interventional
Accepts Healthy Volunteer
-
A Phase 1/2 Study of the Highly Selective EGFR Inhibitor BLU-701 in Patients with EGFR-Mutant Non-Small Cell Lung Cancer
The purpose of the study is to determine the overall safety of the study drug BLU-701, as assessed by the type, frequency, severity, timing, and ...
Phase
Interventional
-
Study to Optimize Immune Coverage of SARS-CoV-2 Existing and Emerging Variants COVAIL Booster Study
The purpose of this research is to test additional vaccine booster shots that use different vaccine types and/or variant spikes to see if these ...Phase
Interventional
Accepts Healthy Volunteer
-
Induction Optimization with Stelara for Crohn s Disease
The purpose of this study is to compare the effectiveness of a second weight based dose of Stelara given intravenously to the standard dose administered ...Phase
Interventional
-
A Phase 1/2a Multi-Center Open-Label Study to Evaluate the Safety Tolerability Pharmacokinetics and Preliminary Evidence of Antitumor Activity of JAB-3312 in combination with pembrolizumab or binimetinib in Adult Patients with Advanced Solid Tumors
The purpose of the study is to determine and demonstrate the safety and tolerability of JAB-3312 in combination with anti-PD-1 or MEKi in patients with ...Phase
Interventional
-
A Phase 2/3 Randomized Open-Label Study of Maintenance GRT-C901/GRT-R902 A Neoantigen Vaccine in Combination with Immune Checkpoint Blockade for Patients with Metastatic Colorectal Cancer
The purpose of the study is to demonstrate clinical efficacy and characterize the clinical activity relating to the maintenance therapy with GRT-C901/GRT-R902 in combination ...Phase
Interventional
-
A Phase 1a/1b Study of LY3537982 in Patients with KRAS G12C-Mutant Advanced Solid Tumors
The purpose of the study is to determine and evaluate the safety, tolerability, and preliminary efficacy of oral LY3537982 as monotherapy and as part of ...Phase
Interventional
