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Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE-R33)
The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains ... -
A Phase 2b Double-Blind Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
The purpose of this research study is to see how safe an investigational drug, peresolimab, is and how well it will work to help people ... -
Seeded Cells on Matrix Plug Treating Crohn's Perianal Fistulas (STOMP II)
The purpose of this research study is to determine whether an investigational drug called AVB-114, is safe and effective to treat perianal fistulas in people ... -
A Randomized Double-blind Placebo-Controlled Phase 2 Study to Evaluate the Efficacy Safety Tolerability Pharmacokinetics and Pharmacodynamics of Intravenous TAK-341 in Subjects With Multiple System Atrophy
The main purpose of this study is to assess the effectiveness and safety of TAK-341 in adult subjects with multiple system atrophy. Multiple system atrophy ... -
A multi-cohort randomized Phase 2 open-label study to assess the preliminary efficacy safety and pharmacokinetics of BIVV020 for prevention and treatment of antibody-mediated rejection in adult kidney transplant recipients.
Antibody-mediated rejection (AMR) remains as the most common cause of allograft failure following kidney transplantation. AMR leads to complement-induced inflammation and endothelial injury of the ... -
A SINGLE-ARM PHASE 2 STUDY OF DARATUMUMAB IN PREVIOUSLY TREATED STK11/LKB1 MUTATED NON-SMALL CELL LUNG CANCER
This is a study of a drug combination called daratumumab for patients with advanced lung cancer that has spread to other parts of the body ...
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Safety and Efficacy of the Alleviant System for No-Implant Interatrial Shunt Creation in Patients with Chronic Heart Failure (ALLAY-HF)
The purpose of this study is to evaluate the safety and efficacy of the Alleviant ALV1 System in patients with chronic heart failure (HF) and ... -
TRANSFORM: A 52-week Randomized Placebo-controlled Double-blind Adaptive Phase 2b/3 Trial of Setanaxib with a 52-week Extension Phase in Patients with Primary Biliary Cholangitis (PBC) and Elevated Liver Stiffness
Calliditas Suisse SA (the Sponsor) is conducting a clinical research study to see if an experimental medicine named setanaxib, will help in the treatment of ... -
A Phase II Multicenter Double-Blind Randomised Placebo-Controlled Study and Open-Label Long Term Extension to Evaluate the Safety and Efficacy of Elafibranor in Adult Participants with Primary Sclerosing Cholangitis (PSC)
This study will evaluate the effects of elafibranor (the study drug) in participants with Primary Sclerosing Cholangitis (PSC). PSC is a rare disease of the ... -
Randomized Double-Blind Placebo-Controlled Study to Evaluate the Effects of EP547 in Subjects with Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis
Intense. Unrelenting. Distressing. Itching.
If you have itch due to liver disease, consider participating in pruritus research. The PACIFIC study is testing an investigational drug ...