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DAY101-001/PNOC026/FIREFLY-1: A Phase 2 Open-Label Multicenter Study to Evaluate the Safety and Efficacy of the Oral Pan-RAF Inhibitor DAY101 in Pediatric Patients with RAF-Altered Recurrent or Progressive Low-Grade Glioma and Advanced Solid Tumors
DAY101 is an oral, selective, small-molecule, Type II pan-RAF kinase inhibitor that is being developed by DOT Therapeutics-1 Inc. (Day One, the Sponsor) for the ...Phase
Interventional
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Organized sports participation among patients who have undergone Ponseti treatment for Idiopathic Clubfoot
A retrospective chart review of patients treated for clubfoot. Participation involves completing a one-time survey asking for demographic, physical activity, and sports participation information. Surveys ...Phase N/A
Non-Interventional
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Proactive infliximab optimization using a pharmacokinetic dashboard versus standard of care in patients with Crohn s disease: The OPTIMIZE Trial
This is a randomized, controlled, multicenter, open-label study. All eligible subjects will be randomly assigned in a 1:1 ratio to receive either IFX monotherapy ...Phase N/A Interventional
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AGCT1531: A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs.Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
The aim of this study for low and standard risk germ cell tumor (GCT) patients is to minimize toxicity by reducing therapy while maintaining current ...Phase
Interventional
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ACNS2021: A Phase 2 Trial of Chemotherapy followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in ...Phase
Interventional
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Phase 3 multicenter randomized double-blind group sequential placebo-controlled study to assess efficacy and safety of rimegepant for the treatment of migraine (with or without aura) in children and adolescents = 6 to
The main purpose of this study is to learn how well the study drug works and how safe the study drug is in children and ...Phase
Interventional
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Movement Disorder Genomic Study
With the present study we aim to perform integrated genomic analysis and study on subject-specific cellular models in order to identify genetic causes of rare ...Phase N/A Non-Interventional
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Genetic Screening Outcomes in Movement Disorders
Understanding the correlation between genetic mutations and causative pathogenic mechanisms and phenotypes in Movement Disorders may significantly contribute to implementing therapeutic approaches for these conditions ...Phase N/A Non-Interventional
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Psoriatic Response and Onset: Genes Radiology Environment Skin and Synovium)
This is a longitudinal, observational cohort study to aimed to understand the clinical and biologic underpinnings of psoriasis and psoriatic arthritis development and severity. To ...Phase N/A Non-Interventional
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Wolff-Parkinson-White Syndrome in Children
This is a prospective study with the aim to create a database of pediatric patients with Wolff-Parkinson-White syndrome. The overarching goal is to provide information ...Phase N/A Non-Interventional
