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Long-acting buprenorphine vs. naltrexone opioid treatments in CJS-involved adults (EXIT CJS)
This study seeks to meaningfully address the U.S. opioid epidemic by comparing the effectiveness of two medications used to treat opioid use disorder, extended-release ...Phase
Interventional
Accepts Healthy Volunteer
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Preventing Arthritis in a Multi-Center Psoriasis At-Risk Cohort (Multi-Center PAMPA Study)
This is a multi-center (North-America), randomized, double-blind, placebo-controlled, wait-list, interventional, preventive trial of guselkumab in high-risk psoriasis patients compared to non-biologic standard of care. Population ...Phase
Interventional
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Depression treatment and A dynamics: A study of Alzheimer s disease risk (ABD Study)
The study will use a randomized 8-week double-blind placebo controlled parallel trial using escitalopram to test the associations between depressive symptoms (captured by the MADRS ...Phase
Interventional
Accepts Healthy Volunteer
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Randomized Controlled Open-Label Parallel Group Multi-Center Prospective Phase 4 Study Comparing the Efficacy of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2 3 and 4 Pressure Injuries
This post-marketing study is being performed to assess the effectiveness of Altrazeal® Transforming Powder Dressing (“Altrazeal®” or “TPD”) manufactured by ULURU Inc. in patients with ...Phase
Interventional
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A Multicenter Randomized Double-Blind Placebo-Controlled Non-inferiority Crossover Study Evaluating the Safety and Immunogenicity of the Herpes Zoster Subunit Vaccine in Patients with Systemic Lupus Erythematosus
This randomized, double-blind, placebo-controlled, non-inferiority crossover study will evaluate the HZ/su vaccine in SLE patients in order to evaluate safety and immunogenicity in patients ...Phase
Interventional
Accepts Healthy Volunteer
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AFFIRM: A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Effect of Seladelpar on Clinical Outcomes in Patients with Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
This is a Phase 4 multicenter evaluation of seladelpar, administered as a once-daily oral capsule, in a randomized, double-blind, placebo-controlled, parallel-group study in patients with ...Phase
Interventional
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Treat-to-Target Serum Urate versus Treat-to-Avoid Symptoms in Gout: A Randomized Controlled Trial (TRUST trial)
The purpose of this research study is to compare two different treatment strategies and see if they may improve the signs and symptoms of gout ...Phase
Interventional
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The Global Paradise System US Post Approval Study (US GPS)
The objective of the Global GPS Registry is to evaluate the real-world use of the Paradise System as per approved labeling. In addition, US GPS ...Phase
Interventional
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A Multi-Center Prospective Non-Interventional Study of Real-World Effectiveness of Etrasimod in Patients with Ulcerative Colitis (ENDEAVOUR-UC)
The purpose of this research study is to observe the effectiveness of Etrasimod (Velsipity®) in adults with moderately to severely active ulcerative colitis (UC).
The ...Phase
Interventional
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AN OPEN-LABEL TREATMENT WITH RANDOMIZATION OBSERVATION INVESTIGATOR-INITIATED STUDY ON THE DURATION AND EFFICACY OF JORNAY PM (METHYLPHENIDATE HYDROCHLORIDE EXTENDED-RELEASE CAPSULES) ON ADULT ADHD SYMPTOMS AND EXECUTIVE FUNCTION AND EMOTIONAL REGULATION THROUGHOUT THE DAY INTO EARLY EVENING
The purpose of this research study is to examine the efficacy of Jornay PM on Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms and Executive Function throughout the ...Phase
Interventional
