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A Phase II Clinical Trial to Study the Efficacy and Safety of Pembrolizumab (MK-3475) in Subjects with High Risk Non-muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG) Therapy
In this study, participants with high risk non-muscle-invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette Guerin (BCG) therapy and who are considered ineligible for or ...
Phase
Interventional
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Phase II: Adaptive De-escalation of Radiation Therapy Dose In Favorable Risk HPV-Positive Oropharyngeal Carcinoma (ART)
The main goal of this study is to determine if deescalating chemoradiation treatment based on early tumor shrinkage at mid-treatment can result in similar cancer ...
Phase
Interventional
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APEC1621SC: NCI-COG PEDIATRIC MATCH (MOLECULAR ANALYSIS FOR THERAPY CHOICE) SCREENING PROTOCOL
If you or your child have cancer that has become worse following treatment, or because no standard therapy exists for your type of cancer, you ...Phase
Non-Interventional
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NMTRC14: NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)
If you or your child have been diagnosed with neuroblastoma that is now in remission, you or your child may be qualified to participate in ...Phase
Interventional
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A Phase II Open Label Study of IMMU-132 in Metastatic Urothelial Cancer After Failure of Platinum-Based Regimen or Anti-PD-1 / PD-L1 Based Immunotherapy
If you have been diagnosed with urothelial cancer that has progressed or returned, you may be qualified for this Phase 2 study. The main goal ...Phase
Interventional
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Anti-viral therapy in Alzheimer's disease
This study is being conducted to evaluate if the generic anti-viral medication, valacyclovir, is helpful in treating Alzheimer's disease in patients who have tested positive ...Phase
Interventional
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Transcranial Direct Current Stimulation (tDCS) for the Management of Multiple Sclerosis Related Fatigue
The purpose of this study is to determine if tDCS (short for transcranial direct current stimulation) can be used to manage the MS symptoms of ...Phase
Interventional
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A single arm open-label multicenter phase II study of 177Lu-DOTATATE radionuclide in adults with progressive or high-risk meningioma
The purpose of this research study is to test whether Lutathera® (177Lu-DOTATATE) is effective (how well something works) at stopping the growth of meningiomas. This ...Phase
Interventional
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A Phase 2 Randomized Study of Adjuvant Immunotherapy With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab Versus Pembrolizumab Alone After Complete Resection of High-Risk Melanoma (mRNA-4157-P201)
The purpose of this research study is to test whether the combination of the study drugs pembrolizumab and mRNA-4157 works better than just pembrolizumab to ...Phase
Interventional
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NN8640-4245 - A dose-finding trial evaluating the effect and safety of once-weekly treatment of somapacitan compared to daily Norditropin in children with short stature born small for gestational age with no catch-up growth by 2 years of age or older
This research study involves children born small and who stayed small. Treatment is somapacitan once a week compared to Norditropin® once a day. Researchers will ...Phase
Interventional
