Displaying 540 (all) recruiting clinical trials.
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A Modular Phase I/II Open-label Multicentre Study to Evaluate the Safety Tolerability and Efficacy of AZD3470 a PRMT5 Inhibitor as Monotherapy and in Combination With Anticancer Agent(s) in Participants With Relapsed/Refractory Haematologic Malignancies
This is a Phase I/II, open-label, multicentre clinical study that is testing AZD3470, an investigational oral medicine, in people with blood cancers (haematologic malignancies ...
Phase
Interventional
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Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure: A Crossover Trial
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with ...Phase
Interventional
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Community-Engaged Approach to Supporting South Asians with Type 2 Diabetes at Risk for Depression
The purpose of this research study is to understand the causes of Type 2 diabetes and depression in South Asians. For this portion of the ...Phase
Interventional
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A Phase 1b Open-label Study of CLN-978 for the Treatment of Active Moderate to Severe Sjogren s Disease
The purpose of this study is to investigate the safety, tolerability, and effectivness of an investigational drug called CLN-978 in patients with active Sjogren’s ...Phase
Interventional
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A Phase 2 Randomized Double-Blind Study to Evaluate the Efficacy Safety and Tolerability of Different Veverimer Dose Regimens in Adults with CKD and Metabolic Acidosis
The objective of this 26-week study is to evaluate the efficacy and safety of veverimer in treating adults with moderate-to-severe chronic kidney disease (CKD) and ...Phase
Interventional
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Tensi+ for treating Overactive Bladder: A 2 Randomized Controlled Trial
The purpose of this study is to investigate the safety and efficacy of the device Tensi+ in reducing symptoms of overactive bladder (OAB), such as ...Phase
Interventional
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A Phase III Multicentre Randomised Open-label Study to Compare the Efficacy and Safety of AZD0486 plus Rituximab versus Chemotherapy plus Rituximab in Previously Untreated Participants with Follicular Lymphoma (SOUNDTRACK-F1)
This is a Phase III study testing a new treatment for people with untreated follicular lymphoma (FL). The study will compare surovatamig combined with rituximab ...
Phase
Interventional
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Building a multidisciplinary transition readiness clinic for adolescents and young adults with inflammatory bowl disease using the TRAQ
The purpose of this study is to evaluate a structured transition program for adolescents and young adults with inflammatory bowel disease (IBD) at the NYU ...Phase N/A
Non-Interventional
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A Phase II Study of the Interferon Gamma Inhibitor Emapalumab for Prophylaxis of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome in Patients with Lymphoma and Multiple Myeloma Receiving Bispecific T-Cell Engagers.
This is a Phase 2, non-randomized study testing emapalumab, a medicine that blocks a protein called interferon gamma (IFN-y). The goal of this study is ...
Phase
Interventional
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Transcatheter Tricuspid Valve Replacement using the Medtronic Intrepid TTVR System in patients with Severe Symptomatic Tricuspid Regurgitation (PATHFINDER)
This study tests whether the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) system is safe and works well for people with a badly leaking tricuspid ...Phase
Interventional
