Displaying 50 (all) recruiting clinical trials.
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A PHASE 0/I STUDY TO ASSESS THE SAFETY AND TOLERABILITY OF XRD-0394 IN COMBINATION WITH RADIATION THERAPY IN PATIENTS WITH HIGH GRADE GLIOMAS
This is an open-label, dose-finding study of XRD-0394 in subjects with newly diagnosed and recurrent high grade gliomas receiving radiation therapy, with and without concurrent ...Phase
Interventional
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A Phase I Clinical Study to Evaluate the Safety Tolerability Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Subjects with Advanced Solid Tumors
This is a Phase 1 study testing the study medicine GSK5733584 (B7-H4 targeted antibody-drug conjugate (ADC )) in patients with advanced solid tumors. The study drug ...
Phase
Interventional
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A Phase 1 Open-Label Multicenter Study of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
To evaluate the safety, tolerability, and DLTs and determine the MTD and/or RDE(s) of INCA33890 in participants with select advanced or metastatic solid ...Phase
Interventional
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A Phase 1 First in Human Randomized Placebo-controlled Trial with a Controlled Gluten Challenge to Evaluate Safety Tolerability Pharmacokinetics and Pharmacodynamics of VTP-1000 in Adults with Celiac Disease
The purpose of this research study is to test a possible new treatment for celiac disease called VTP 1000.Phase
Interventional
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A PHASE 1A/B OPEN-LABEL MASTER STUDY OF PF-07799544 AS A SINGLE-AGENT AND IN COMBINATION WITH OTHER TARGETED AGENTS IN PARTICIPANTS WITH BRAF-MUTANT MELANOMA AND OTHER SOLID TUMORS
This is a first-in-human, open-label, Phase 1a/b master protocol to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of PF-07799544 (also ...Phase
Interventional
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A Phase 1 Study of ICP-248 in Combination with Azacitidine for the Treatment in Patients with Myeloid Malignancies
This is a phase 1, open-label, multicenter study with two parts that will assess the safety profile, PK profile, and preliminary efficacy of ICP-248 in ...Phase
Interventional
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A Phase 1 First-in-Human Study of MEN2312 a KAT6 Inhibitor as Monotherapy and in Combination in Participants With Advanced Breast Cancer
This is the first study in people to test a new drug called MEN2312 (an experimental cancer drug) for the treatment of advanced breast cancer ...
Phase
Interventional
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A Study of a Selective ERBB2 Inhibitor CGT4255 in Patients With Advanced Solid Tumors With ERBB2 Genetic Alterations or HER2 Overexpression
This is a study testing a new medicine called CGT4255 for patients with advanced cancers (like lung cancer or breast cancer) that have certain mutations ...
Phase
Interventional
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A Phase 1/2 Open-Label Multicenter First-in-Human Study of the Safety Tolerability Pharmacokinetics and Antitumor Activity of BH-30643 in Adult Subjects with Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations (SOLARA)
This is a Phase 1/2 study testing a medicine called BH-30643, a new drug that targets and blocks specific mutations (changes) in two proteins ...
Phase
Interventional
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AN OPEN-LABEL PHASE 1 SAFETY AND DOSE FINDING STUDY OF ORALLY ADMINISTERED GLIX1 IN ADULTS WITH RECURRENT OR PROGRESSIVE HIGH-GRADE GLIOMA
This is an open label (meaning both doctors and participants know what treatment is given), first study in humans, done at several medical centers, for ...
Phase
Interventional
