Displaying 591 (all) recruiting clinical trials.
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A Phase II Clinical Trial to Study the Efficacy and Safety of Pembrolizumab (MK-3475) and Pembrolizumab in Combination with Other Investigational Agents in Subjects with High-risk Non-muscle-Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG) Therapy
This is a single arm, multi-site, open-label trial of pembrolizumab (MK-3475) in subjects with high risk non-muscle-invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette Guerin ...Phase
Interventional
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PHASE II: ADAPTIVE TREATMENT DE-ESCALATION IN FAVORABLE RISK HPV-POSITIVE OROPHARYNGEAL CARCINOMA
This will be a phase II single-arm clinical trial. The primary objective of this study is to evaluate progression-free survival at 2 years. The secondary ...Phase
Interventional
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Prospective Randomized Three Arm Study of lumbar Spinal Fusion Graft Efficacy: Bone marrow aspirate concentrate & Allograft versus Recombinant Bone Morphogenetic Protein-2 (BMP) versus Control Group
This study will be a prospective, randomized clinical study at a single-center, NYU Langone Medical Center. It is intended to compare and evaluate the efficacy ...Phase N/A Interventional
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Mechanisms and Enhancement of Learning During Sleep
Memory dysfunction represents one of the most common cognitive complaints in patients with epilepsy and significantly impairs quality of life. Our work aims to (1 ...Phase
Non-Interventional
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A Phase 1 Open-Label Multicenter Study to Assess the Safety Tolerability and Immunogenicity of mRNA-4157 Alone or in Combination in Participants with Solid Tumors
This is a 2-part, open-label, Phase 1, multicenter dose-escalation, FIH study of mRNA-4157 monotherapy in subjects with resected solid tumors (Part A) who are in ...Phase
Interventional
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APEC1621SC: NCI-COG PEDIATRIC MATCH (MOLECULAR ANALYSIS FOR THERAPY CHOICE) SCREENING PROTOCOL
The Pediatric MATCH (Molecular Analysis for Therapy Choice) study, (referred to as Pediatric MATCH in the remainder of this document), will match targeted agents with ...Phase
Non-Interventional
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NMTRC014: NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)
High risk Neuroblastoma (HR NB) remains a challenge in pediatric oncology, accounting for 15% of all pediatric cancer deaths. While most patients are able to ...Phase
Interventional
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PNH Registry
Alexion Pharmaceuticals, Inc. has been the Sponsor of a global PNH Registry since August 2004 and enrolling patients with PNH worldwide. The primary aim of ...Phase
Non-Interventional
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Controlling Behcet's Uveitis Through Transfer of Ex-Vivo Expanded Regulatory T Cells
The purpose of this study is to see whether we can massively expand autoantigen-specific Treg clones from patients with Behcet's Disease (BD), in particular ...Phase N/A Non-Interventional
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NYU Validation of a Food Frequency Questionnaire in Children and Adolescents
The pathogenesis of Type 1 Diabetes (T1D) is still incompletely understood. Markers of autoimmunity and immunologic changes occur prior to the development of elevated blood ...Phase N/A Non-Interventional
