Displaying 565 (all) recruiting clinical trials.
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Site for A Multi-Center Prospective Randomized Controlled Trial Comparing the Safety and Effectiveness of prodisc C SK and prodisc C Vivo to Mobi-C Cervical Disc in the Treatment of Two-Level Symptomatic Cervical Disc Disease (SCDD)
Research study to evaluate the safety and effectiveness of prodisc C SK and prodisc C Vivo versus Mobi-C (currently available on market).Phase
Interventional
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Non-invasive biomarkers for neonatal outcomes in preterm infants
Despite modern advances that have greatly improved the health outcomes for preterm infants, the field of neonatology still lacks reliable prognostic tools for many disorders ...Phase N/A
Non-Interventional
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Microbial and human biomarkers of thoracic disease after lung transplantation
We will prospectively collect airway and blood samples on 200 subjects undergoing lung transplantation. We will evaluate airway microbial signatures associated with local (lower airway ...Phase N/A Non-Interventional
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Multi-Center Prospective Evaluation of Complex Adult Spinal Deformity Surgery (CADS)
The goal of this study is to evaluate surgical treatment outcomes of complex adult spinal deformity patients, including radiographic and clinical outcomes, surgical and postoperative ...Phase N/A Non-Interventional
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New onset refractory status epilepticus (NORSE)
This is a multi-site study aiming at creating a biorepository of a rare disease, new onset refractory status epilepticus (NORSE), to establish clinical characteristics, outcomes ...Phase N/A Non-Interventional
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WUH: COG# AGCT1531: A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
?Despite recent improvements in outcome for children with newly diagnosed high-risk neuroblastoma, cure rates remain unsatisfactory. Further, these gains have been the result of interventions ...Phase
Interventional
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WUH: "ANBL1531: A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)"
?Despite recent improvements in outcome for children with newly diagnosed high-risk neuroblastoma, cure rates remain unsatisfactory. Further, these gains have been the result of interventions ...Phase
Interventional
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Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
The primary purpose of the study is to determine if accelerated BEP (Bleomycin, Etoposide, cisPlatin) is effective and tolerable for patients with advanced gem cell ...
Phase
Interventional
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Study of inherited monogenic disorders in patient and tissue-specific cells
We propose to collect blood samples to reprogram into patient-specific neuronal, cardiac, and cancer cell lines (see below in the background section) from patients diagnosed ...Phase N/A Non-Interventional
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ACNS1833: A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
Low-grade gliomas (LGG) are the most common central nervous system tumor among children, accounting for approximately one-third of pediatric brain tumors. These tumors include a ...Phase
Interventional
