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A PHASE IB-II STUDY OF HIGH-DOSE POST-TRANSPLANT CYCLOPHOSPHAMIDE BORTEZOMIB AND ABATACEPT FOR THE PREVENTION OF GRAFT-VERSUS-HOST DISEASE (GVHD) FOLLOWING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT)
The purpose of the study is to determine if the administration of the investigational prophylactic medications: PTCy, bortezomib and abatacept, for individuals with hematological malignancies ...
Phase
Interventional
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A phase 2 open-label single-arm cohort study to evaluate the safety efficacy and pharmacokinetics of sparsentan treatment in pediatric subjects with selected proteinuric glomerular diseases (EPPIK)
The purpose of this research study is to study if an investigational drug (one that is not FDA approved), named sparsentan, will help in the ...Phase
Interventional
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Prospective Randomized Placebo-Controlled Trial of SurVaxM Plus Adjuvant Temozolomide for Newly Diagnosed Glioblastoma (SURVIVE)
You can participate in this study if you are newly diagnosed with brain cancer (glioblastoma). The purpose of this study is to evaluate a peptide ...
Phase
Interventional
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A Phase 2a Multicenter Randomized Double blind Study Evaluating the Efficacy and Safety of Subcutaneously Administered combination therapy in Improving the Signs and Symptoms in Participants with Active Psoriatic Arthritis.
The purpose of this study is to see if guselkumab and golimumab, when used together, are safe and effective for treating participants with active Psoriatic ...Phase
Interventional
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A Randomized Double-blind Placebo controlled Multi-center 2-part Phase 2 Study to Evaluate Efficacy Safety and Tolerability of RGH-706 in Prader-Willi Syndrome
The hypothalamus is a small but complex part of the brain. It is an important regulator of body temperature, appetite, and hormone secretion. The hypothalamus ...Phase
Interventional
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An Open-Label Study of CK-3773274 for Patients with Symptomatic Hypertrophic Cardiomyopathy (HCM)
HCM is a condition in which the heart muscle becomes abnormally thickened, which can sometimes block the blood flow out of the heart, and the ...Phase
Interventional
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Assessment of the Efficacy Safety and Pharmacokinetics of Alpelisib (BYL719) in Patients with PIK3CA-related Overgrowth Spectrum (PROS)
The purpose of this research study is to assess whether alpelisib is safe and has beneficial effects in people with a confirmed diagnosis of PI3KCA-related ...Phase
Interventional
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A Phase II study of Atezolizumab and Bevacizumab in Child-Pugh B7 Hepatocellular Carcinoma.
You can participate in this study if you are diagnosed with advanced liver cancer. The purpose of this study is to determine the efficacy and ...Phase
Interventional
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Efficacy Safety and Tolerability of BI 1291583 QD Over at least 24 Weeks in Patients with Bronchiectasis
This study is being done to see if the study drug called BI 1291583 may help people with bronchiectasis. Participants in the study may receive ...Phase
Interventional
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Efficacy Safety and Pharmacokinetics of Rozanolixizumab in Adult Study Participants with Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis
The purpose of this study is to see if rozanolixizumab, an investigational (new) drug, is able to prevent the worsening of symptoms of Leucine-Rich Glioma ...Phase
Interventional
