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A double blind randomised placebo-controlled trial evaluating the efficacy and safety of nerandomilast over 26 weeks in patients with Systemic Autoimmune Rheumatic Diseases associated Interstitial Lung Diseases (SARD-ILD)
The purpose of this research study is to test a new drug called nerandomilast in participants with Systemic Auto-immune Rheumatic Diseases associated Interstitial Lung Diseases ...Phase
Interventional
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Interventional randomized double-blind placebo-controlled optional open-label extension trial of Lu AF82422 in participants with Multiple System Atrophy.
The purpose of this trial is to investigate whether Lu AF82422 is safe and effective in treating patients with multiple system atrophy (MSA). This trial ...Phase
Interventional
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A Phase III Randomised Double-blind Placebo-controlled Event-driven Study to Assess the Efficacy Safety and Tolerability of Baxdrostat in Combination with Dapagliflozin Compared with Dapagliflozin Alone on Renal Outcomes and Cardiovascular Mortality in Participants with Chronic Kidney Disease and High Blood Pressure
The purpose of this study is to investigate the efficacy, safety and tolerability of baxdrostat in combination with dapagliflozin, compared with placebo and dapagliflozin intreating ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Placebo-Controlled Multicenter Study to Investigate the Efficacy Safety and Tolerability of LP352 in the Treatment of Seizures in Children and Adults with Dravet Syndrome
The purpose of this study is to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children (2-17) and adults ...Phase
Interventional
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An Open-Label Randomized Controlled Multi-Center Study of The Efficacy of Daromun (L19IL2 + L19TNF) Neoadjuvant Intratumoral Treatment Followed by Surgery and Adjuvant Therapy VS Surgery and Adjuvant Therapy in Clinical Stage IIIB/C/D Melanoma Patients
The primary objective of the study is to demonstrate that a neoadjuvant Daromun treatment followed by surgery and adjuvant therapy improves in a statistically significant ...Phase
Interventional
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A Phase 3 Double-Blind Placebo-Controlled Randomized Study to Assess the Safety of Epicutaneous Immunotherapy with DBV712 250 g in 1-through 3-year-old Children with Peanut Allergy
The purpose of this study is to learn how well an investigational drug patch (DBV712) works and how safe it is compared with a placebo ...Phase
Interventional
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80202135SJS3001/DAFFODIL - A Randomized Placebo-controlled Double-blind Multicenter Phase 3 Protocol to Assess the Efficacy and Safety of Nipocalimab in Adults with Moderate to Severe Sj gren's Disease (SjD)
The purpose of this study is to see if nipocalimab is safe and useful for treating patients with Sjögren’s disease. Available treatment options for ...Phase
Interventional
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AREN2231: Risk Adapted Treatment of Unilateral Favorable Histology Wilms Tumors (FHWT)
This phase III trial studies using risk factors in determining treatment for children with favorable tissue (histology) Wilms tumors (FHWT). Wilms Tumor is the most ...Phase
Interventional
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A Phase 3 Open-label Randomized Study Assessing the Efficacy and Safety of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for PIK3CA-mutant HR+ HER2- Locally Advanced or Metastatic Breast Cancer
This is a Phase 3 study testing whether the study medicine RLY-2608 (selective inhibitors of PI3Ka) along with fulvestrant (standard hormone therapy) is more effective ...
Phase
Interventional
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NRG-GI011 A Phase III Randomized Trial of Dose Escalated Radiation in Locally Advanced Pancreas Cancer (LAPC) Patients (LAP100)
NRG-GI011, A Phase III Randomized Trial of Dose Escalated Radiation in Locally Advanced Pancreas Cancer (LAPC) Patients (LAP100)Phase
Interventional
