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AN EIGHTEEN MONTH OBSERVATIONAL INVESTIGATION OF PARTICIPANTS WITH OPEN ANGLE GLAUCOMA AND A DOCUMENTED HISTORY OF PROGRESSIVE VISUAL FIELD LOSS: ASSESSING THE REPRODUCIBILITY AND RESPONSIVENESS OF OUTCOME MEASURES OF GLAUCOMA PROGRESSION
This is a 18 month observational study in individuals who have any form of open angle glaucoma with Humphrey visual field (HVF) 24-2 SITA standard ...Phase N/A
Non-Interventional
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The ConsideRAte study. A multipart exploratory study to evaluate splenic nerve stimulation in patients with rheumatoid arthritis.
The ConsideRAte study This study will evaluate the safety, tolerability, and effects of stimulating the splenic neurovascular bundle (NVB) with an active implantable medical device ...Phase N/A
Interventional
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A Single-Center Observational Study of Targeted Muscle Reinnervation in Amputees
This is a prospective, observational, longitudinal study that will follow the course of recovery for amputees who undergo targeted muscle reinnervation for treatment of limb ...Phase N/A Non-Interventional
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EARLY DETECTION OF ALPHA-SYNUCLEIN DISEASE Single-center cross-sectional and longitudinal non-interventional observational study of biomarkers in prodromal synucleinopathy
Single-center, cross-sectional and longitudinal exploratory observational study of approximately 80 patients with diagnoses of pure autonomic failure (PAF), Parkinson´s Disease, Multiple System Atrophy, Lewy ...Phase N/A Non-Interventional
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Patient Expectations Following Flexor Tendon Repair - a Qualitative Analysis
The primary aim of this study is to evaluate patients’ expectations following flexor tendon repair. We hypothesize that patients will have overly optimistic expectations and ...Phase N/A Non-Interventional
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Elucidating Neural Mechanisms and Sex Differences in Response to Mindfulness Based Stress Reduction in Generalized Anxiety Disorder
Mindfulness-Based Stress Reduction (MBSR) has demonstrated efficacy for Generalized Anxiety Disorder (GAD), yet there remains a major knowledge gap about its neural mechanisms. Neuroimaging studies ...Phase N/A Interventional
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Site for AN INTERVENTIONAL MULTI-CENTER INVESTIGATION OF SINGLE LEVEL TRANSFORAMINAL LUMBAR INTERBODY FUSION (TLIF) STABILIZED WITH PEDICLE SCREWS
Site for An interventional, multi-center (up to 15), prospective, non-blinded investigation of single-level TLIF stabilized with pedicle screws. The purpose is to intend to treat ...Phase N/A Interventional
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A Multi-Center Observational Study Assessing the Utility of an Immune Cell Function Assay in a Cardiac Sarcoid Population
Sarcoid is an autoimmune disease that can be found in any and every organ system. The greatest degree of morbidity and mortality comes from cardiac ...Phase N/A Non-Interventional
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Paradoxical Lucidity in Severe End-Stage Dementia: A Mixed Methods Prospective Study
Cognitive decline in dementia is considered irreversible, however episodes of paradoxical lucidity (PL) in severe dementia suggest other mechanisms may be in play. Beyond anecdotal ...Phase N/A Non-Interventional
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A Randomized Comparative Effectiveness Study of Staged Complete Revascularization with Percutaneous Coronary Intervention to Treat Coronary Artery Disease vs Medical Management Alone in Patients with Symptomatic Aortic Valve Stenosis undergoing Elective Transfemoral Transcatheter Aortic Valve Replacement: The COMPLETE TAVR Study
This study is being conducted in Aortic Stenosis patients who have undergone successful TAVR with a balloon expandable heart valve who also have coronary artery ...Phase N/A Interventional
