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A Phase 2 Double-Blind Placebo-Controlled Single-Dose Study of Pharmacodynamics Pharmacokinetics Safety and Tolerability of REGN7544 an NPR1 Antagonist Monoclonal Antibody in Patients with Postural Orthostatic Tachycardia Syndrome
The purpose of this research study is to research an experimental drug called REGN7544. The study is focused on participants with postural orthostatic tachycardia syndrome ...Phase
Interventional
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A Phase 2 Open-label Randomized Study of V940 in Combination With BCG Versus BCG Monotherapy in Participants With High-risk Non-muscle Invasive Bladder Cancer (INTerpath-011)
This study is designed to compare the antitumor activity of V940 in combination with BCG to BCG monotherapy, and evaluate safety of both treatments, in ...Phase
Interventional
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A Phase 2 randomized open-label active-controlled study of JNJ-90301900 in combination with chemoradiation followed by durvalumab in locally advanced and unresectable Stage III non-small cell lung cancer
This is a Phase 2 study testing whether adding a new medicine, JNJ-90301900 (radioenhancer) to the standard treatment of chemotherapy and radiation, followed by a ...
Phase
Interventional
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A Phase II multisite open-label single arm trial of BNT327 in combination with docetaxel in second-line stage IV non-small cell lung cancer (NSCLC) following chemoimmunotherapy
This is a phase 2 study testing a new medicine, BNT327 (an investigational antibody), together with another medicine called docetaxel (standard chemotherapy treatment) to find ...
Phase
Interventional
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A Phase II multicenter open-label trial of tagraxofusp (Tag) in combination with venetoclax and azacitidine (Ven/Aza) in adults with previously untreated CD123+ acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy
This study looks at how safe and effective a medicine called Tag is when combined with Ven and Aza for people with CD123+ acute myeloid ...
Phase
Interventional
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A Multi-center Randomized Open-label Parallel-group Phase 2 Study to Evaluate the Efficacy and Safety of VS-101 in Combination with Chemoradiotherapy (CRT) in Patients with Head and Neck Cancer
This is a Phase 2 study testing the study medicine VS-101 (an oral radiosensitizer) in combination with Chemoradiotherapy (CRT) in patients with head and neck ...
Phase
Interventional
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PNOC022: A Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas (DMGs) including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis Post-Radiation Therapy and at Time of Progression
This research is for kids and young adults who have a specific kind of brain tumor called DMG (Diffuse Midline Gliomas). We're testing different ...
Phase
Interventional
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Phase II Trial of SMO/ AKT/ NF2/CDK Inhibitors in Progressive Meningiomas with SMO/ AKT/ NF2/CDK Pathway Mutations
This is a phase 2 study testing how well the study medicines vismodegib (a Hedgehog pathway inhibitor), GSK2256098 (a selective focal adhesion kinase (FAK) inhibitor ...
Phase
Interventional
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GS-US-457-6411: A Phase 2 Double-Blinded Randomized Placebo-Controlled Dose-Ranging Study Evaluating the Efficacy and Safety of GS-5290 in Participants with Moderately to Severely Active Ulcerative Colitis
The goal of this study is to learn if investigational drug tilpisertib fosmecarbil (formerly known as GS-5290) is effective and safe in treating participants with ...Phase
Interventional
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A Phase 2 Randomized Double-Blind Placebo-Controlled Multicenter Dose Ranging Study Evaluating the Efficacy and Safety of GS-1427 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)
The study team is evaluating an oral investigational drug to see if it reduces the signs and symptoms of moderately to severely active ulcerative colitis ...Phase
Interventional
