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VEDOKIDS study: Predicting response to Vedolizumab in Pediatric Inflammatory Bowel Diseases including drug levels: a multi-center prospective Pan- European cohort study (P-ECCO and ESPGHAN)
The purpose of this research study is to learn more about a medication used to treat crohns and ulcerative colitis. Subjects are invited to participate ... -
AALL1631: International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Ph+ ALL Testing Imatinib in Combination with Two Different Cytotoxic Chemotherapy Backbones
The goal of this trial is to reduce treatmentrelated morbidity and mortality without adversely impacting disease free survival (DFS) in Standard Risk (SR) patients, who ... -
A Multi-Center Prospective Randomized Controlled Trial Comparing the Safety and Effectiveness of prodisc C SK and prodisc C Vivo to Mobi-C Cervical Disc in the Treatment of Two-Level Symptomatic Cervical Disc Disease (SCDD)
The purpose of this research study is to see if the prodisc C SK and prodisc C Vivo (cervical disc replacement devices) are safe and ... -
WUH: Impact of medical and surgical weight loss on lipocalin prostaglandin D2 synthase (LPGDS) and bile acid levels.
Obesity and type 2 diabetes are medical conditions that are associated with significant health risks. These include stroke, heart disease, and kidney disease. Medical research ... -
Microbial and human biomarkers of thoracic disease after lung transplantation
The purpose of this study is to identify biological markers associated with lung inflammation and immune responsiveness in lung transplantation. The study will prospectively collect ... -
Multi-Center Prospective Evaluation of Complex Adult Spinal Deformity Surgery (CADS)
The purpose of this study is to evaluate the surgical outcomes of adults with complex spinal deformity at multiple centers across the United States. While ... -
New Onset Refractory Status Epilepticus (NORSE)
The purpose of this study is to establish a research bank of data and biospecimens for future research on new onset refractory status epilepticus (NORSE ... -
TSPO-ligand PET imaging in autoimmune epilepsy
The purpose of this study is to use PET/MRI imaging to measure levels of inflammation in the brain of people with autoimmune epilepsy compared ... -
WUH: Characterization of microsomal triglyceride transfer protein (MTP) in metabolic and gastrointestinal tissue in obese and other subjects undergoing therapeutic surgeries.
Microsomal triglyceride transfer protein (MTP) is an enzyme that is responsible for fat and cholesterol metabolism. Blocking the effect of MTP may be helpful in ... -
A Phase 3 Study of I-Metaiodobenzylguanidine or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)
?The primary purpose of the study is to assess the effectiveness and safety of targeted radiopharmaceutical therapy with 131I-MIBG or crizotinib for patients with high-risk ...