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DISCOVER: A single-site double-blind placebo-controlled randomized mechanistic crossover trial to assess the influence of boDy weIght on aSpirin-triggered speCialized prO-resolVing mEdiatoRs
Aspirin is commonly used to prevent heart attacks and strokes in clinical care. Commonly a “baby” aspirin (81mg) is prescribed for this purpose. However, higher ...Phase
Interventional
Accepts Healthy Volunteer
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A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02D
The purpose of the study is to determine the efficacy of investigational agents with or without pembrolizumab for the treatment of PD-1 naïve or PD-1 ...Phase
Interventional
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A Phase 1/2 Study of CPI-0209 Monotherapy and in Combination with Other Therapy in Patients with Advanced Solid Tumors
The purpose of the study is to evaluate the safety and tolerability of the study drug CPI-0209 as monotherapy and in combination with irinotecan in ...Phase
Interventional
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A Single-Center Observational Study to Develop EEG Biomarkers of Transition from Acute to Chronic Pain
The purpose of this research study is to examine electroencephalogram or EEG (which measures brain activity) in subjects with acute low back pain to develop ...Phase N/A
Non-Interventional
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Surveillance After Extremity Tumor Surgery International Randomized Controlled Trial
The purpose of this research study is to determine whether the frequency of follow-up after surgery (visits every 3 months vs every 6 months) or ...Phase N/A Interventional
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STK-001-DS-501 - An Open-Label Extension Study for Patients with Dravet Syndrome who Previously Participated in Studies of STK 001
The purpose of this research study is to look at a possible new therapy for Dravet syndrome, called STK-001. Dravet syndrome is a severe form ...Phase
Interventional
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Reverse End to Side Transfer for Severe Cubital Tunnel Syndrome
The purpose of this research study is to look for differences in outcomes between two different surgical treatments for cubital tunnel syndrome.Phase N/A Non-Interventional
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Mesoscopic Biomarkers of Neurodegeneration and Inflammation with Diffusion MRI
The purpose of this study is to track both neurodegeneration and inflammation in multiple sclerosis (MS) disease progression by taking pictures using Magnetic Resonance Imaging ...Phase N/A Non-Interventional
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A Prospective Registry for the Study of Outcomes and Predictors in Pouchitis and Pouch-Related Disorders
The purpose of this study is to collect information of patients with pouch-related conditions. The information gathered during the study will help us know more ...Phase N/A Non-Interventional
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A Phase 1b/2 Randomized Study of AVB-S6-500 Plus Nab-paclitaxel and Gemcitabine in Patients With Locally Advanced or Metastatic Pancreatic Adenocarcinoma
The purpose of the study is to evaluate the safety and efficacy of AVB-S6-500 in combination with nab-paclitaxel and gemcitabine in subjects with locally advanced ...Phase
Interventional
