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Study to Optimize Immune Coverage of SARS-CoV-2 Existing and Emerging Variants COVAIL Booster Study
The purpose of this research is to test additional vaccine booster shots that use different vaccine types and/or variant spikes to see if these ...Phase
Interventional
Accepts Healthy Volunteer
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Induction Optimization with Stelara for Crohn s Disease
The purpose of this study is to compare the effectiveness of a second weight based dose of Stelara given intravenously to the standard dose administered ...Phase
Interventional
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Autologous Intraarticular Micro-Fragmented Adipose Transfer
The purpose of this study is to determine if transferring fat tissue from your lower abdomen or outer thigh into the base of the thumb ...Phase
Interventional
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A Phase II Study to Evaluate the Efficacy and Safety of GT90001 in Combination with Nivolumab as a Second-line Treatment in Subjects with Advanced Hepatocellular Carcinoma
The purpose of the study is to examine and assess the antitumor activities of Nivolumab in combination with GT90001 or Nivolumab alone in subjects with ...
Phase
Interventional
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A Phase 2 Randomized Double-Blind Placebo-Controlled Efficacy and Safety Study of VIB7734 for the Treatment of Moderate to Severely Active Systemic Lupus Erythematosus
The purpose of this study is to learn how well VIB7734 is tolerated in patients with SLE, to determine if it causes any side effects ...Phase
Interventional
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A Multi-Center Randomized Double-blind Placebo-controlled Dose-finding Study to Evaluate the Safety Tolerability Pharmacokinetics and Pharmacodynamics of CK-3773274 in Adults with Symptomatic Hypertrophic Cardiomyopathy
Some people with HCM have obstructive HCM (oHCM) and other participants have non-obstructive HCM (nHCM). HCM is a condition in which the heart muscle becomes ...Phase
Interventional
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A randomized double-blind placebo-controlled study of ALPN-101 in systemic lupus erythematosus.
Lupus is a disease that occurs when your body's immune system is active in a way that can injure your own healthy tissues and ...Phase
Interventional
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A Phase 2 Trial of Chemotherapy followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor
If you or your child has been newly diagnosed with a brain tumor called Non-Germinomatous Germ Cell Tumor (NGGCT) there may be an opportunity to ...
Phase
Interventional
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Phase 2b Clinical Study Evaluating Efficacy and Safety of TAR-200 in Combination with Cetrelimab TAR-200 Alone or Cetrelimab Alone in Participants with High-Risk Non- Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guerin (BCG) who are Ineligible for or Elected Not to Undergo Radical Cystectomy
The purpose of the study is to determine the efficacy and safety of TAR-200 in combination with Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in participants ...Phase
Interventional
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A PHASE IB-II STUDY OF HIGH-DOSE POST-TRANSPLANT CYCLOPHOSPHAMIDE BORTEZOMIB AND ABATACEPT FOR THE PREVENTION OF GRAFT-VERSUS-HOST DISEASE (GVHD) FOLLOWING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT)
The purpose of the study is to determine if the administration of the investigational prophylactic medications: PTCy, bortezomib and abatacept, for individuals with hematological malignancies ...
Phase
Interventional
