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E-cigarettes for Harm Reduction Among Smokers with Serious Mental Illness
The purpose of this research study is to compare the effectiveness of electronic cigarettes and telehealth counseling versus nicotine replacement therapy (patches, lozenges and gum ...Phase
Interventional
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5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
The purpose of this double-blind randomized study is to explore the efficacy of psilocybin (5-HT2A receptor agonist psilocybin) as a smoking cessation treatment. In this ...
Phase
Interventional
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AbbVie M21-446 - A Single-Arm Open-Label Study to Evaluate the Efficacy and Safety of ABBV-668 in Subjects With Moderate to Severe Ulcerative Colitis
The purpose of this study is to see if the study drug called ABBV-668 is safe and effective at treating moderate to severe ulcerative colitis.Phase
Interventional
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A Phase 2 Randomized Double-Blind Placebo-Controlled Study to Assess the Efficacy and Safety of Barzolvolimab (CDX-0159) in Adults with Active Eosinophilic Esophagitis
The purpose of this study is to see if the study drug Barzolvolimab (CDX-0159) is safe and effective at treating Active Eosinophilic Esophagitis (EoE). The ...Phase
Interventional
Accepts Healthy Volunteer
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A Phase 2 Randomized Study to Evaluate the Optimized Dose Safety and Efficacy of Livmoniplimab in Combination with Budigalimab for Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) Patients who Have Progressed After an Immune Checkpoint Inh
This research study aims to find out if two medicines, livmoniplimab (a special drug used to boost the body's ability to fight liver cancer ...
Phase
Interventional
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Brightline-2: A Phase IIa/IIb open-label single-arm multi-centre trial of BI 907828 for treatment of patients with locally advanced / metastatic MDM2 amplified TP53 wild-type biliary tract adenocarcinoma pancreatic ductal adenocarcinoma or other se
The purpose of the trial is to study a drug called BI 907828 for the treatment of certain types of advanced or spreading tumors. These ...
Phase
Interventional
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The Janus Rectal Cancer Trial: A Randomized Phase II Trial Testing the Efficacy of Triplet Versus Doublet Chemotherapy to Achieve Clinical Complete Response in Patients with Locally Advanced Rectal Cancer
This study will focus on improving chemotherapy response rates in both primary and metastatic rectal and colorectal cancer. In this study, patients will be divided ...
Phase
Interventional
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A single arm phase II study of ADjuvant Endocrine therapy subcutaneous Pertuzumab and Trastuzumab fixed-dose combination for patients with anatomic stage I hormone receptor-positive HER2-positive breast cancer (ADEPT)
You can participate in this study if you are diagnosed with stage I, hormone receptor-positive (HR+) and human epidermal growth factor receptor-2.positive (HER2+) breast ...
Phase
Interventional
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A Phase 2 Study of Futibatinib in Combination with PD-1 Antibody-based Standard of Care Therapy in Patients with Solid Tumors
This study wants to see if a new medicine called futibatinib, when used with pembrolizumab (a type of treatment that helps the immune system fight ...
Phase
Interventional
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A Phase II Open-Label Multicenter Randomized Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
This is a study testing two different treatments for patients with pancreatic cancer after surgery. The study team want to see if adding two drugs ...
Phase
Interventional
