-
NRG-BR009: A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1 ER Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score = 25 (OFSET)
This study wants to see if giving extra chemotherapy (adjuvant chemotherapy (ACT) to ovarian function suppression plus endocrine therapy) helps premenopausal women with early-stage breast ...
Phase
Interventional
-
The Anti-Inflammatory Effects of Milk-Derived Extracellular Vesicles in Preterm Infant
The purpose of this study is to examine and compare Milk-Derived Extracellular Vesicles (EVs) in three types of milk: mothers' own milk, donor milk, and ...Phase N/A
Non-Interventional
-
Noninvasive Vagal Nerve Stimulation for the Management of Symptoms Experienced in Multiple Sclerosis (VANISH-MS): An Open-Label Home-Based Study of taVNS and tcVNS Compared to tDCS
Noninvasive brain stimulation devices are increasingly being used to enhance functioning in individuals living with MS. We are interested in identifying the most effective stimulation ...Phase N/A Interventional
-
Randomized Evaluation of Bromocriptine in Myocardial Recovery Therapy (REBIRTH) for Peripartum Cardiomyopathy
The purpose of the study is to test the use of a drug called bromocriptine for women who have a condition called “Peripartum cardiomyopathy” or ...Phase
Interventional
-
EXpanding Prenatal cell free DNA screening Across moNogenic Disorders (EXPAND)
The purpose of this research is to develop and validate a single gene Non-Invasive Prenatal Test. The development of this investigational single-gene noninvasive prenatal testing ...Phase N/A Non-Interventional
-
Defining the Impact of Peyronie s Disease on Sexual Quality of Life for Partners
In this study we will interview female partners of patients with Peyronie's disease about the impact of the disease on their sexual quality of ...Phase N/A Non-Interventional
-
Pathways to Oral Health Among Low-income Pregnant Urban Women
The purpose of this study is to find out how oral health changes during pregnancy and what makes it difficult for a woman to have ...Phase N/A Non-Interventional
Accepts Healthy Volunteer
-
AKTive-001: A Phase 1/1b Multiple Cohort Trial of ALTA2618 in Patients with Advanced Solid Tumors with AKT1 E17K Mutation
This trial is designed to test the effectiveness of ALTA2618 in patients with advanced solid tumors that have a specific genetic mutation (AKT1 E17K). The ...
Phase
Interventional
-
Phase 3 Randomized Open-label Multicenter Study to Compare the Efficacy and Safety of Sacituzumab Tirumotecan in Combination with Pembrolizumab Versus Pembrolizumab Alone as First-line Maintenance Treatment in Participants with Mismatch Repair Proficient Endometrial Cancer (TroFuse-033/GOG-3119/ENGOT-en29)
This is a Phase 3 trial testing whether the study medicine sacituzumab tirumotecan (an antibody-drug conjugate, also known as sac-TMT, or MK-2870), when given in ...
Phase
Interventional
-
A Phase 3 Randomized Open-label Study of Rinatabart Sesutecan (Rina-S) versus Treatment of Investigator s Choice (IC) in Patients with Platinum Resistant Ovarian Cancer (GOG 3107)
This study is being done to compare a new treatment, Rina-S, to standard chemotherapy in patients with a type of ovarian cancer that no longer ...
Phase
Interventional
