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TAILOR RT: A RANDOMIZED TRIAL OF REGIONAL RADIOTHERAPY IN BIOMARKER LOW RISK NODE POSITIVE BREAST CANCER
The purpose of this study is to determine whether there is any benefit of regional radiotherapy and to compare good and bad effects of not ...Phase
Interventional
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Combining Estrogen and Prolonged Exposure therapy for symptoms of PTSD
The purpose of this research study is to determine if taking a pill of estradiol (a form of estrogen) together with prolonged exposure (PE) therapy ...Phase
Interventional
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RANDOMIZED PLACEBO-CONTROLLED SINGLE BLINDED MULTICENTER STUDY EVALUATING THE EFFICACY AND SAFETY OF YONI.FIT IN WOMEN WITH STRESS URINARY INCONTINENCE (SUI)
This study will look at how safe and how well the investigational device, Yo¯ni.Fit® device works in improving the symptoms of stress urinary ...Phase
Interventional
Accepts Healthy Volunteer
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A Phase 3 Open-label Extension Study to Assess the Long-term Safety and Efficacy of Intravenous ATB200 Co-administered With Oral AT2221 in Adult Subjects With Late-onset Pompe Disease
The purpose of this study is to find out if an investigational new drug called ATB200 and AT2221 can help people with Pompe disease and ...Phase
Interventional
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A Phase 3 Randomized Double- Or Observer-Blinded Placebo-Controlled Trial to Evaluate the Efficacy and Safety of a Respiratory Syncytial Versus (RSV) Prefusion F Subunit Vaccine in Infants Born To Women Vaccinated During Pregnancy
The purpose of this study is to find out if Pfizer’s investigational RSVpreF vaccine prevents the development of RSV illness in your baby. A ...Phase
Interventional
Accepts Healthy Volunteer
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Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly
Fetal complete (i.e., third degree) atrioventricular block (AVB), identified in the 2nd trimester of pregnancy in an otherwise normally developing heart, is almost universally ...Phase
Interventional
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A Phase III Randomized Placebo-Controlled Study of Pembrolizumab (MK-3475 NSC #776864) in Addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA Stage IVB or Recurrent Endometrial Cancer
The purpose of the study is to determine if we can lower the chance of your endometrial cancer growing or spreading by adding a new ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Study of Pembrolizumab versus Placebo in Combination with Adjuvant Chemotherapy with or without Radiotherapy for the Treatment of Newly Diagnosed High-Risk Endometrial Carcinoma After Surgery with Curative Intent (MK3475 B21/ENGOT-en11/GOG-3053)
The purpose of the study is to determine and compare pembrolizumab and adjuvant chemotherapy with placebo and adjuvant chemotherapy, with or without radiotherapy, in relation ...Phase
Interventional
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The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): COMPASSHER2 Residual Disease (RD) A Double-Blinded Phase III Randomized Trial of T-DM1 Compared with T-DM1 and Tucatinib
The purpose of the study is to determine if the invasive disease-free survival (iDFS) with T-DM1 and tucatinib is superior to the iDFS in the ...Phase
Interventional
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Melanoma Margins Trial (MelMarT): A Phase III Multi-Centre Multi-National Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma.
You can participate in this study if you are diagnosed with skin melanoma stage 2. This study will determine whether there is a difference in ...Phase
Interventional
