Displaying 715 (all) recruiting clinical trials.
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DAY101-001/PNOC026/FIREFLY-1: A Phase 2 Open-Label Multicenter Study to Evaluate the Safety and Efficacy of the Oral Pan-RAF Inhibitor DAY101 in Pediatric Patients with RAF-Altered Recurrent or Progressive Low-Grade Glioma and Advanced Solid Tumors
DAY101 is an oral, selective, small-molecule, Type II pan-RAF kinase inhibitor that is being developed by DOT Therapeutics-1 Inc. (Day One, the Sponsor) for the ...Phase
Interventional
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The ConsideRAte study. A multipart exploratory study to evaluate splenic nerve stimulation in patients with rheumatoid arthritis.
The ConsideRAte study This study will evaluate the safety, tolerability, and effects of stimulating the splenic neurovascular bundle (NVB) with an active implantable medical device ...Phase N/A Interventional
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A Phase 1 Open-label Preliminary Pharmacokinetics (PK)and Safety Study of CLN-049 (An fms-like tyrosine kinase 3 [FLT3] x cluster of differentiation 3 [CD3] bispecific T cell engager) in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
A Phase 1, Open-label, Preliminary Pharmacokinetics (PK)and Safety Study of CLN-049 (An fms-like tyrosine kinase 3 [FLT3] x cluster of differentiation 3 [CD3] bispecific ...Phase
Interventional
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A Single-Center Observational Study of Targeted Muscle Reinnervation in Amputees
This is a prospective, observational, longitudinal study that will follow the course of recovery for amputees who undergo targeted muscle reinnervation for treatment of limb ...Phase N/A
Non-Interventional
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Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations (IND 156083)
A Phase II randomized trial will be initiated to evaluate efficacy of FGF-2 in treatment of chronic non-healing tympanic membrane perforation. This study is a ...Phase
Interventional
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EARLY DETECTION OF ALPHA-SYNUCLEIN DISEASE Single-center cross-sectional and longitudinal non-interventional observational study of biomarkers in prodromal synucleinopathy
Single-center, cross-sectional and longitudinal exploratory observational study of approximately 80 patients with diagnoses of pure autonomic failure (PAF), Parkinson´s Disease, Multiple System Atrophy, Lewy ...Phase N/A Non-Interventional
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Elucidating Neural Mechanisms and Sex Differences in Response to Mindfulness Based Stress Reduction in Generalized Anxiety Disorder
Mindfulness-Based Stress Reduction (MBSR) has demonstrated efficacy for Generalized Anxiety Disorder (GAD), yet there remains a major knowledge gap about its neural mechanisms. Neuroimaging studies ...Phase N/A Interventional
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Site for AN INTERVENTIONAL MULTI-CENTER INVESTIGATION OF SINGLE LEVEL TRANSFORAMINAL LUMBAR INTERBODY FUSION (TLIF) STABILIZED WITH PEDICLE SCREWS
Site for An interventional, multi-center (up to 15), prospective, non-blinded investigation of single-level TLIF stabilized with pedicle screws. The purpose is to intend to treat ...Phase N/A Interventional
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A First in Human Study of theMenin-KMT2A (MLL1)Inhibitor JNJ-75276617 in Participants with Acute Leukemia
A First in Human Study of theMenin-KMT2A (MLL1)Inhibitor JNJ-75276617 in Participants with Acute LeukemiaPhase
Interventional
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Organized sports participation among patients who have undergone Ponseti treatment for Idiopathic Clubfoot
A retrospective chart review of patients treated for clubfoot. Participation involves completing a one-time survey asking for demographic, physical activity, and sports participation information. Surveys ...Phase N/A Non-Interventional
