Displaying 757 (all) recruiting clinical trials.
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First-in-human open-label dose-escalation trial with expansion cohorts to evaluate safety of GEN1046 in subjects with malignant solid tumors
The purpose of the study is to determine the safety of GEN1046 in patients with malignant solid tumors. GEN1046 is investigational drug in this study ...Phase
Interventional
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The Effect of Tranexamic Acid on Calculated Total Blood Loss in Anticoagulated patients undergoing Total Shoulder Arthroplasty
The purpose of this research study is to compare how well Tranexamic Acid (TXA) reduces total blood loss, surgical drain output (fluids released at the ...Phase
Interventional
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A Double-blind Placebo-controlled Multi-centre Clinical Trial to Investigate the Efficacy and Safety of 24 Months of Therapy With Inhaled Colistimethate Sodium in the Treatment of Subjects With Non-cystic Fibrosis Bronchiectasis Chronically Infected Wi
This study aims to obtain information on the efficacy and safety of a drug called colistimethate sodium in comparison with a placebo, administered twice daily ...Phase
Interventional
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A Phase II Study of Talimogene laherparepvec Followed by Talimogene laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas Cutaneous Squamous Cell Carcinoma Merkel Cell Carcinoma and Other Rare Skin Tumors
The purpose of the study is to determine the safety and efficacy of talimogene laherparepvec monotherapy followed by combination therapy with nivolumab (NIVO) for patients ...Phase
Interventional
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MULTICENTER PHASE II NEOADJUVANT AND ADJUVANT STUDY OF ALECTINIB ENTRECTINIB OR VEMURAFENIB PLUS COBIMETINIB IN PATIENTS WITH STAGES I-III NON-SMALL CELL LUNG CANCER WITH ALK ROS1 NTRK OR BRAF V600E MOLECULAR ALTERATIONS
The purpose of the trial is to determine the efficacy and safety of drugs in patients with untreated non-small cell lung cancer (NSCLC) tumors. In ...Phase
Interventional
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An Observational Longitudinal Oligo-Center Study to Define Clinical Biofluid Imaging and Digital Outcome Measures in Multiple System Atrophy
This research study is an observational, non-interventional, study to define changes in clinical, neurological, blood, spinal fluid, and neuroimaging (MRI) biomarkers (A biomarker is a ...Phase N/A
Non-Interventional
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COVID-19 Study for New and Expecting Moms
This is a study that will examine the impact of COVID-19 on experiences of pregnant and new mothers and the relevance of these experiences to ...Phase N/A Non-Interventional
Accepts Healthy Volunteer
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ADVANCED DIFFUSION IMAGING IN RENAL TISSUE: TECHNICAL OPTIMIZATION
The objective of this study is to optimize imaging protocols and analysis for advanced magnetic resonance imaging (MRI) of the kidney.The study will see ...Phase N/A Non-Interventional
Accepts Healthy Volunteer
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Alzheimer s Disease Research Center
The purpose of this study is to study the diagnosis, clinical course, risk factors, causes and treatment of cognitive impairment in aging, Alzheimer’s disease ...Phase N/A Non-Interventional
Accepts Healthy Volunteer
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A phase 3 randomized trial for patients with de novo AML comparing standard therapy including gemtuzumab ozogamicin GO to CPX-351 with GO and the addition of the FLT3 inhibitor gilteritinib for patients with FLT3 mutations
The purpose of the study is to compare standard chemotherapy to therapy with CPX-351 and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia ...Phase
Interventional
