Displaying 641 (all) recruiting clinical trials.
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A Phase 2 Dose finding Randomized Double-blind Placebo controlled Multicenter Study to Evaluate the Safety and Efficacy of Efavaleukin Alfa Induction Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis
The main purpose of this study is to evaluate the effect of efavaleukin alfa on induction of clinical remission in participants with moderately to severely ...Phase
Non-Interventional
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Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients A Pragmatic Trial (EVOLUTION).
This research study is being conducted to determine whether switching to an IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab ...Phase N/A
Interventional
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Advancing Cath Lab Results with FFRangio Coronary Physiology Assessment: The ALL-RISE Study
The primary objective of this trial is to test whether FFRangio®-guided treatment is noninferior to conventional pressure wire-guided treatment in patients with coronary artery ...Phase N/A Interventional
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Assessing dysarthria severity before and after neurosurgical procedures: A prospective longitudinal study in patients with refractory movement disorders
Subjects undergoing the neurosurgical high intensity focused ultrasound (HIFU) procedure as part of their standard of care for Essential Tremor (ET) will perform three sessions ...Phase N/A Non-Interventional
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Site for RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Site for This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems ...Phase
Interventional
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A PHASE III RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED MULTICENTER BASKET STUDY TO EVALUATE THE EFFICACY SAFETY PHARMACOKINETICS AND PHARMACODYNAMICS OF SATRALIZUMAB IN PATIENTS WITH ANTI-N-METHYL-D-ASPARTIC ACID RECEPTOR (NMDAR) OR ANTI-LEUCINE-RICH GLIOMA-INACTIVATED 1 (LGI1) ENCEPHALITIS
The purpose of this study is to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of satralizumab in participants with anti-N-methyl-D-aspartic acid receptor (NMDAR) and anti-leucine-rich ...Phase
Interventional
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Safety and Tolerability of GTX-104 (Nimodipine Injection for IV Infusion) Compared with Oral Nimodipine in Patients Hospitalized for Aneurysmal Subarachnoid Hemorrhage (aSAH): a Prospective Randomized Trial
This safety study is a Phase 3, prospective, open-label, randomized (1:1 ratio), parallel group study of GTX-104 (nimodipine injection for IV infusion) compared with ...Phase
Interventional
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A PHASE 2 MULTICENTER MULTINATIONAL RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED STUDY TO ASSESS THE SAFETY EFFICACY AND PHARMACOKINETICS OF MULTIPLE DOSE LEVELS OF ESK 001 IN ADULT PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Overall Design: This is a Phase 2, multicenter, multinational, randomized, double blind, placebo controlled study to evaluate the safety, efficacy, PK, and PD of 3 ...Phase
Interventional
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Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)
This is a Phase 2 randomized, open-label, two-part, multicenter study with a safety run-in to evaluate efficacy and safety of DKN-01 plus FOLFIRI/FOLFOX and ...Phase
Interventional
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TECHNICAL DEVELOPMENT OBSERVATIONAL STUDY FOR MRI IMAGE ACQUISITION
In study, we develop new software for image acquisition of MRI up to and including 3T magnet strength and compare the image quality metrics of ...Phase N/A Interventional
