Displaying 675 (all) recruiting clinical trials.
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New onset refractory status epilepticus (NORSE)
This is a multi-site study aiming at creating a biorepository of a rare disease, new onset refractory status epilepticus (NORSE), to establish clinical characteristics, outcomes ...Phase N/A
Non-Interventional
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TSPO-ligand PET imaging in autoimmune epilepsy
This study will investigate the role of TSPO-PET imaging in autoimmune epilepsy, to quantify and visualize neuroinflammation. This study may support the role for TSPO-PET ...Phase N/A Non-Interventional
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WUH: COG# AGCT1531: A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
?Despite recent improvements in outcome for children with newly diagnosed high-risk neuroblastoma, cure rates remain unsatisfactory. Further, these gains have been the result of interventions ...Phase
Interventional
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Site for WUH: AGCT1532: Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
Site for To determine if accelerated BEP (Bleomycin, Etoposide, cisPlatin) is superior to standard BEP as first-line chemotherapy for intermediate and poor-risk metastatic GCTs.Phase
Interventional
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Study of inherited monogenic disorders in patient and tissue-specific cells
We propose to collect blood samples to reprogram into patient-specific neuronal, cardiac, and cancer cell lines (see below in the background section) from patients diagnosed ...Phase N/A Non-Interventional
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ACNS1833: A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
Low-grade gliomas (LGG) are the most common central nervous system tumor among children, accounting for approximately one-third of pediatric brain tumors. These tumors include a ...Phase
Interventional
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Single-Center Pilot Study of Living Donor Kidney Transplant from HIV-positive Donor to HIV-positive Recipient
This study will evaluate the feasibility and safety of living donor kidney transplant from an HIV-infected donor to an HIV-infected recipient.Phase N/A Non-Interventional
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A single-center observational study of the natural history and pathogenesis of hidradenitis suppurativa
A single-center observational study of the natural history and pathogenesis of hidradenitis suppurativaPhase N/A Non-Interventional
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A 12-week randomized double-blind placebo-controlled trial investigating the effects of Levetiracetam in early psychosis
This is a 12-week study of levetiracetam in conjunction with a second generation antipsychotic in early psychosis patients with treatment-resistant symptoms. Treatment with antipsychotics has ...Phase
Interventional
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Site for ACNS1833: A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
Site for This trial studies how well selumetinib works in treating patients with low-grade glioma. Selumetinib is a drug that works by blocking a protein ...Phase
Interventional
