Displaying 365 (all) recruiting clinical trials.
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Site for WUH: Circulating Exosome Effects on Cholesterol Handling: Impact on Cardiovascular Risk in Obesity
Site for Atherosclerotic cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Obesity increases risk for coronary heart disease and stroke. Prevention ...Phase N/A
Non-Interventional
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VEDOKIDS study: Predicting response to Vedolizumab in Pediatric Inflammatory Bowel Diseases including drug levels: a multi-center prospective Pan- European cohort study (P-ECCO and ESPGHAN)
Vedolizumab (VDZ) is a humanized immunoglobulin G1 monoclonal antibody acting against a4ß7 integrin which modulates lymphocyte trafficking in the gut. Results from the adult GEMINI-1 ...Phase N/A Non-Interventional
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Site for WUH: Impact of medical and surgical weight loss on lipocalin prostaglandin D2 synthase (LPGDS) and bile acid levels.
Site for Eligible participants for this study will include adult patients undergoing (1) weight loss surgery or (2) participating in Winthrop’s Weight Management Program ...Phase N/A Non-Interventional
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Non-invasive biomarkers for neonatal outcomes in preterm infants
Despite modern advances that have greatly improved the health outcomes for preterm infants, the field of neonatology still lacks reliable prognostic tools for many disorders ...Phase N/A Non-Interventional
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Microbial and human biomarkers of thoracic disease after lung transplantation
We will prospectively collect airway and blood samples on 200 subjects undergoing lung transplantation. We will evaluate airway microbial signatures associated with local (lower airway ...Phase N/A Non-Interventional
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Multi-Center Prospective Evaluation of Complex Adult Spinal Deformity Surgery (CADS)
The goal of this study is to evaluate surgical treatment outcomes of complex adult spinal deformity patients, including radiographic and clinical outcomes, surgical and postoperative ...Phase N/A Non-Interventional
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New onset refractory status epilepticus (NORSE)
This is a multi-site study aiming at creating a biorepository of a rare disease, new onset refractory status epilepticus (NORSE), to establish clinical characteristics, outcomes ...Phase N/A Non-Interventional
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TSPO-ligand PET imaging in autoimmune epilepsy
This study will investigate the role of TSPO-PET imaging in autoimmune epilepsy, to quantify and visualize neuroinflammation. This study may support the role for TSPO-PET ...Phase N/A Non-Interventional
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Characterization of microsomal triglyceride transfer protein (MTP) in metabolic and gastrointestinal tissue in obese and other subjects undergoing therapeutic surgeries.
Site for Obesity (BMI>30) is often associated with type-2 diabetes and metabolic syndrome (1). The gain in body weight is mainly due to increase ...Phase N/A Non-Interventional
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Study of inherited monogenic disorders in patient and tissue-specific cells
We propose to collect blood samples to reprogram into patient-specific neuronal, cardiac, and cancer cell lines (see below in the background section) from patients diagnosed ...Phase N/A Non-Interventional
