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A Phase 1 First in Human Study of ARV-393 in Adult Participants with Advanced Non-Hodgkin s Lymphoma
This is a multicenter, open-label Phase 1 study testing a new drug called ARV-393 in adults with advanced non-Hodgkin lymphoma (NHL). The study will look ...
Phase
Interventional
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A Phase 1a/b Study Investigating the Safety Tolerability Pharmacokinetics Pharmacodynamics and Preliminary Antitumor Activity of BGB-58067 an MTA-Cooperative PRMT5 Inhibitor in Patients With Advanced Solid Tumors
This is an open-label, multicenter, first-in-human dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BGB-58067 ...Phase
Interventional
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A Phase 1 Randomized Double-Blind Study to Evaluate the Safety and Tolerability of a Vaccine against E. coli in Healthy Adults
This is a Phase 1, randomized, observer-blind study to evaluate the safety, and tolerability, of FimH modRNA and O25b conjugate (with or without adjuvant) vaccine ...Phase
Interventional
Accepts Healthy Volunteer
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A Phase 1 Open-Label Study to Evaluate the Safety Tolerability Pharmacokinetics and Efficacy of BL-M07D1 in Subjects with HER2 Expressing Advanced Malignant Solid Tumors
This is a multicenter Phase 1 study evaluating the safety, tolerability, pharmacokinetic (PK) profile, and initial efficacy of BL-M07D1 in subjects with metastatic or unresectable ...Phase
Interventional
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A PHASE 0/I STUDY TO ASSESS THE SAFETY AND TOLERABILITY OF XRD-0394 IN COMBINATION WITH RADIATION THERAPY IN PATIENTS WITH HIGH GRADE GLIOMAS
This is an open-label, dose-finding study of XRD-0394 in subjects with newly diagnosed and recurrent high grade gliomas receiving radiation therapy, with and without concurrent ...Phase
Interventional
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Safety and Efficacy of Topical Bacteriotherapy for Atopic Dermatitis Using Staphylococcus Hominis A9
The study aims to investigate the safety of applying a gel containing a bacteria called S. hominis A9 to the skin on participants with atopic ...Phase
Interventional
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A Phase I Clinical Study to Evaluate the Safety Tolerability Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Subjects with Advanced Solid Tumors
This is a Phase 1 study testing the study medicine GSK5733584 (B7-H4 targeted antibody-drug conjugate (ADC )) in patients with advanced solid tumors. The study drug ...
Phase
Interventional
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A Phase 1 Open-Label Multicenter Study of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
To evaluate the safety, tolerability, and DLTs and determine the MTD and/or RDE(s) of INCA33890 in participants with select advanced or metastatic solid ...Phase
Interventional
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A Phase 1 First in Human Randomized Placebo-controlled Trial with a Controlled Gluten Challenge to Evaluate Safety Tolerability Pharmacokinetics and Pharmacodynamics of VTP-1000 in Adults with Celiac Disease
The purpose of this research study is to test a possible new treatment for celiac disease called VTP 1000.Phase
Interventional
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A phase 1 placebo-controlled dose-escalation study of the safety pharmacokinetics and antiviral activity of a potent neutralizing monoclonal antibody in individuals with chronic hepatitis B infection
The purpose of this research study is to evaluate the safety and tolerability of intravenous (through a vein in your arm) infusions of a new ...Phase
Interventional
