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Phase 1 Open-Label Multicenter Dose Escalation Study of mRNA-2752 a Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L IL-23 and IL-36? for Intratumoral Injection Alone and in Combination with Immune Checkpoint Blockade
The purpose of the study is to evaluate the anti-tumor activity of ITu injections of mRNA-2752 alone and in combination with intravenously administered durvalumab in ...Phase
Interventional
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Gut Kidney Axis in Enteric Hyperoxaluria
The purpose of this research study is to study the effects of enteric hyperoxaluria (EH) when they are given a pre-prepared diet. EH is a ...Phase
Interventional
Accepts Healthy Volunteer
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A Randomized Double-Blind Placebo-Controlled Sequential Phase I Study to Evaluate Safety Tolerability Pharmacokinetics and Pharmacodynamics of CT-G20 in Subjects with Hypertrophic Obstructive Cardiomyopathy
The purpose of the study is to determine the safety and tolerability of CT-G20 (the study drug) in subjects with obstructive hypertrophic cardiomyopathy (oHCM). The ...Phase
Interventional
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Optimized MRI of patients with hip arthroplasty
In patients with hip replacement, the metal of the artificial hip darkens the magnetic resonance imaging (MRI) images which is called shadowing. The purpose of ...Phase
Interventional
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A Phase 1/1b Open-label Multicenter Study to Investigate the Safety Tolerability Pharmacokinetics and Antitumor Activity of KIN-2787 in Participants with BRAF and/or NRAS Mutation-positive Solid Tumors.
You can participate in this study if you are diagnosed with stage 3 or stage 4 skin melanoma. The purpose of this study is to ...Phase
Interventional
