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A Phase 1 Randomized Double-Blind Study to Evaluate the Safety and Tolerability of a Vaccine against E. coli in Healthy Adults
This is a Phase 1, randomized, observer-blind study to evaluate the safety, and tolerability, of FimH modRNA and O25b conjugate (with or without adjuvant) vaccine ...Phase
Interventional
Accepts Healthy Volunteer
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A Phase 1 Open-Label Study to Evaluate the Safety Tolerability Pharmacokinetics and Efficacy of BL-M07D1 in Subjects with HER2 Expressing Advanced Malignant Solid Tumors
This is a multicenter Phase 1 study evaluating the safety, tolerability, pharmacokinetic (PK) profile, and initial efficacy of BL-M07D1 in subjects with metastatic or unresectable ...Phase
Interventional
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A PHASE 0/I STUDY TO ASSESS THE SAFETY AND TOLERABILITY OF XRD-0394 IN COMBINATION WITH RADIATION THERAPY IN PATIENTS WITH HIGH GRADE GLIOMAS
This is an open-label, dose-finding study of XRD-0394 in subjects with newly diagnosed and recurrent high grade gliomas receiving radiation therapy, with and without concurrent ...Phase
Interventional
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A Phase I Clinical Study to Evaluate the Safety Tolerability Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Subjects with Advanced Solid Tumors
This is a Phase 1 study testing the study medicine GSK5733584 (B7-H4 targeted antibody-drug conjugate (ADC )) in patients with advanced solid tumors. The study drug ...
Phase
Interventional
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A Phase 1 Open-Label Multicenter Study of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
To evaluate the safety, tolerability, and DLTs and determine the MTD and/or RDE(s) of INCA33890 in participants with select advanced or metastatic solid ...Phase
Interventional
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Phase 1 Dose-Escalation Study of KTX-2001 (an NSD2 Inhibitor) Alone and in Combination with Darolutamide for Metastatic Castration-Resistant Prostate Cancer
This is a multicenter, open-label Phase 1 study in participants with metastatic castration-resistant prostate cancer (mCRPC) to investigate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and ...Phase
Interventional
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A Phase 1 Study of ICP-248 in Combination with Azacitidine for the Treatment in Patients with Myeloid Malignancies
This is a phase 1, open-label, multicenter study with two parts that will assess the safety profile, PK profile, and preliminary efficacy of ICP-248 in ...Phase
Interventional
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A Phase I Trial Combining Triapine with Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
This is a Phase 1 study testing the safety and effectiveness of a medicine called triapine, along with radiation therapy for patients who have recurring ...
Phase
Interventional
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A Phase 1 First-in-Human Study of MEN2312 a KAT6 Inhibitor as Monotherapy and in Combination in Participants With Advanced Breast Cancer
This is the first study in people to test a new drug called MEN2312 (an experimental cancer drug) for the treatment of advanced breast cancer ...
Phase
Interventional
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A Study of a Selective ERBB2 Inhibitor CGT4255 in Patients With Advanced Solid Tumors With ERBB2 Genetic Alterations or HER2 Overexpression
This is a study testing a new medicine called CGT4255 for patients with advanced cancers (like lung cancer or breast cancer) that have certain mutations ...
Phase
Interventional
