Displaying 47 (all) recruiting clinical trials.
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An Open Label First in Human (FIH) Phase 1 Trial of LVGN6051 as Single Agent and in Combination with Keytruda (pembrolizumab) in Advanced or Metastatic Malignancy
The purpose of the study is to look at how your body tolerates LVGN6051, how safe LVGN6051 may be, and how LVGN6051 is taken up ...Phase
Interventional
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Interventional randomized double-blind crossover placebo controlled exploratory phase Ib study investigating the safety tolerability pharmacokinetic and electrocorticographic response of Lu AG06466 in treatment resistant focal epilepsy patients with chronically implanted responsive neurostimulation system (RNS System).
The purpose of this study is to find out about the safety and efficacy (how well something works) of Lu AG06466 for the treatment of ...Phase
Interventional
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A Phase 1b Multicenter Study to Determine the Dose Safety Efficacy and Pharmacokinetics of TRK-950 when Used in Combinations with Selected Anti-Cancer Treatment Regimens in Patients with Selected Advanced Solid Tumors.
The purpose of the study is to evaluateTRK-950 in combination with 1) FOLFIRI or 2) Gemcitabine / Cisplatin or 3) Gemcitabine / Carboplatin or 4) Ramucirumab/Paclitaxel ...Phase
Interventional
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A Pilot Study to Test the Feasibility of a Hybrid Preoperative Physical Therapy Intervention for Patients Undergoing Total Joint Arthroplasty
This study aims to determine the feasibility of implementing a hybrid physical therapy (PT) intervention prior to total joint (hip or knee) replacement surgery for ...Phase
Interventional
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A Phase 1a/1b Study of LY3537982 in Patients with KRAS G12C-Mutant Advanced Solid Tumors
The purpose of the study is to determine and evaluate the safety, tolerability, and preliminary efficacy of oral LY3537982 as monotherapy and as part of ...Phase
Interventional
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Phase 1 Open-Label Multicenter Dose Escalation Study of mRNA-2752 a Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L IL-23 and IL-36? for Intratumoral Injection Alone and in Combination with Immune Checkpoint Blockade
The purpose of the study is to evaluate the anti-tumor activity of ITu injections of mRNA-2752 alone and in combination with intravenously administered durvalumab in ...Phase
Interventional
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A Randomized Double-Blind Placebo-Controlled Sequential Phase I Study to Evaluate Safety Tolerability Pharmacokinetics and Pharmacodynamics of CT-G20 in Subjects with Hypertrophic Obstructive Cardiomyopathy
The purpose of the study is to determine the safety and tolerability of CT-G20 (the study drug) in subjects with obstructive hypertrophic cardiomyopathy (oHCM). The ...Phase
Interventional
